ENAGenomicsUoLhttps://www.ebi.ac.uk/ena/browser/view/PRJEB69298Staphylococci are frequent members of the human skin microbiome. It was previously determined that S. aureus meets widespread antagonism from coagulase- negative staphylococci. Furthermore, cumulative antagonisms by species in the niche correlate with the absence of S. aureus nasal colonisation, supporting collective antagonism trait expression as a barrier. However, genetics factors and adaptive pathways of bacterial interactions remain uncharacterized. Using a two species system, strongly antagonistic inhibitor-producing S. epidermidis B155 was co-cultured with S. aureus SH1000 to identify determinants of competition and resistance using an experimental evolution approach. In the presence of S. epidermidis B155, S. aureus evolved a high relative fitness due to inhibitor resistance after several days of S. epidermidis.ENAfalseStaphylococcus competitionIdentification of genetic determinants associated with competition between S.aureus and S.epidermidis2024-01-312024-01-31PRJEB69298