ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/019/ERR12496519/ERR12496519_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/017/ERR12496517/ERR12496517_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/015/ERR12496515/ERR12496515_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/018/ERR12496518/ERR12496518_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/015/ERR12496515/ERR12496515_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/014/ERR12496514/ERR12496514_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/019/ERR12496519/ERR12496519_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/018/ERR12496518/ERR12496518_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/016/ERR12496516/ERR12496516_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/016/ERR12496516/ERR12496516_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/017/ERR12496517/ERR12496517_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR124/014/ERR12496514/ERR12496514_2.fastq.gzprimaryOK200GenomicsEarly Data Science, Oncology Data Science, AstraZenecaEuropean Bioinformatics Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJEB71928ArrayExpressMice implanted with CT26 tumour cells were divided into two experimental groups (vehicle and ceralasertib) with the aim of assessing changes in intra-tumour T cells (CD3+) after 7 days of treatment with ceralasertib, and 7 days off. At the end of the treatment course, tumour tissue was isolated, chopped and enzymatically digested to generate a single-cell suspension. Cells sorted on CD3 were then processed using Chromium Next GEM Single Cell 5' Kit v2.ENAAtf1, Atr45A, Single-Cell RNA-Seq, Single-Cell RNAseq, Sc RNAseq, Laboratory, Single Cell Gene Expression Profiling, Single-Cell Gene Expression Profiling, Mus domesticus, mouse, scRNA-seq, l(2)k16912, ScRNA seq, atr-I, Single Cell Gene Expression Analysis, 3-b)pyridine., House Mouse, Single-Cell, Single Cell Transcriptome Analysis, 3-b)pyridine, Sc-RNAseq, single cell RNA sequencing, single-cell transcriptome sequencing, single-cell RNA-seq, Atr-1, House, Mus, Gprk-3, Mus musculus domesticus, Atr-I, Seqs, AtrI, Analysis, Mice, Seq, ATR-I, Mus musculus, Single-Cell RNA, DmelCG8224, Single-Cell Transcriptome Analyses, 4-(4-(1-((S(R))-S-methylsulfonimidoyl)cyclopropyl)-6-((3R)-3-methyl-4-morpholinyl)-2-pyrimidinyl)-1H-pyrrolo(2, ScRNAseq, Single-Cell Transcriptome Analysis, Analyses, Swiss, mice, Swiss Mouse, BABO, House Mice, Swiss Mice, Single Cell RNAseq, Single Cell RNA Seq, Transcriptome Analysis, RNA Seq, ATR-1, Single-Cell RNA Seq, Transcriptome Analyses, domesticus, Laboratory Mice, ScRNA-seq, Bab, Single-Cell Transcriptome, Gprk3, RNAseq, AZD6738, AZD-6738, Babo, Mouse, RNA-Seq, l(2)44Fd, house mouse, CG8224, STK-E, Laboratory MouseAtf1, Atr45A, Single-Cell RNA-Seq, Single-Cell RNAseq, Sc RNAseq, Laboratory, Single Cell Gene Expression Profiling, Single-Cell Gene Expression Profiling, Mus domesticus, mouse, scRNA-seq, l(2)k16912, ScRNA seq, atr-I, Single Cell Gene Expression Analysis, 3-b)pyridine., House Mouse, Single-Cell, Single Cell Transcriptome Analysis, 3-b)pyridine, Sc-RNAseq, single cell RNA sequencing, single-cell transcriptome sequencing, single-cell RNA-seq, Atr-1, House, Mus, Gprk-3, Mus musculus domesticus, Atr-I, Seqs, AtrI, Analysis, Mice, Seq, ATR-I, Mus musculus, Single-Cell RNA, DmelCG8224, Single-Cell Transcriptome Analyses, 4-(4-(1-((S(R))-S-methylsulfonimidoyl)cyclopropyl)-6-((3R)-3-methyl-4-morpholinyl)-2-pyrimidinyl)-1H-pyrrolo(2, ScRNAseq, Single-Cell Transcriptome Analysis, Analyses, Swiss, mice, Swiss Mouse, BABO, House Mice, Swiss Mice, Single Cell RNAseq, Single Cell RNA Seq, Transcriptome Analysis, RNA Seq, ATR-1, Single-Cell RNA Seq, Transcriptome Analyses, domesticus, Laboratory Mice, ScRNA-seq, Bab, Single-Cell Transcriptome, Gprk3, RNAseq, AZD6738, AZD-6738, Babo, Mouse, RNA-Seq, l(2)44Fd, house mouse, CG8224, STK-E, Laboratory MousefalsescRNA-seq of mouse immune compartment from tumours treated with ATRi ceralasertib (AZD6738)scRNA-seq of mouse immune compartment from tumours treated with ATRi ceralasertib (AZD6738)2024-02-062024-02-06PRJEB71928