ENAGenomicsShujuanShujuan Anhttps://www.ebi.ac.uk/ena/browser/view/PRJEB79919The purpose of this study was to determine whether newly diagnosed AML patients had changed their intestinal microbes and metabolites. Do these altered metabolites and microbiota have the potential to be used as biomarkers to help diagnose diseases? Notably, the intestinal microbiota and metabolites of AML patients showed notable structural and quantitative alterations at the time of first diagnosis. Beneficial bacteria including Faecalibacterium, Collinsella, Lacticaseibacillus, and Roseburia—as well as butyric acid and acetic acid—were considerably reduced in newly diagnosed AML patients, but Enterococcus and Lactobacillus, especially Enterococcus, were found to be enriched. Subsequent investigation indicated that Enterococcus was a very potential intestinal marker which had a strong negative correlation with the levels of acetic and butyric acid. Crucially, assays for AML identification showed that Enterococcus, butyric acid, and acetic acid had excellent diagnostic effectiveness. Patients' colonizing Enterococcus strains were isolated for pathogen investigation, which revealed that these bacteria have several strong virulence and multiple drug resistance genes characteristics. Thus, we speculate that Enterococcus plays a function for the development of AML as well as its progression.ENAMyelogenous Leukemias, Myelocytic, leukemia, Myelogenous, Acute Myeloblastic, acute myeloblastic leukemia, M1, BUTANOIC ACID, M2, acute myelogenous leukemia, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, acute myeloblastic leukaemia, acute myelogenous leukaemia, Butyrate, Myelocytic Leukemia, Butanoic Acid, butanic acid, Magnesium, Leukemias, Acute Myeloid, Acute Myelocytic Leukemias, AML, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, CH3-[CH2]2-COOH, 1-butanoic acid, butoic acid, Nonlymphoblastic, acute non lymphoblastic leukaemia, Acute Myeloid Leukemias, M1., Myeloid Leukemias, Acute Myelocytic, Acute Nonlymphoblastic, 1-butyric acid, Sodium, acute myeloid, Sodium Butyrate, Butanoate, Acute Nonlymphocytic, propylformic acid, Myeloblastic Leukemia, Acute Myelogenous Leukemia, acute, Acid, Acute myelogenous leukemia, 1-propanecarboxylic acid, Leukemia, Butanoic acid, Magnesium Dibutyrate, Butyric, Myeloblastic, acide butanoique, Dibutyrate, Acute Myelogenous, Acute Myeloblastic Leukemia, susceptibility to, Butyric Acid, Myeloblastic Leukemias, Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, C4:0, Nonlymphocytic, Acute Myeloid Leukemia without Maturation, Acute Myeloid Leukemia with Maturation, propanecarboxylic acid, Sodium Salt, Acute, Acute Nonlymphoblastic Leukemia, n-butanoic acid, Acute Nonlymphocytic Leukemia, 4:0, Acute Nonlymphoblastic Leukemias, Acute Myeloblastic Leukemias, Buttersaeure, Butyric Acid Magnesium Salt, acide butyrique, Myeloid Leukemia, Acute Myelogenous Leukemias, Myelocytic Leukemias, ethylacetic acid, ANLL, Nonlymphoblastic Leukemias, Butanoic, n-butyric acid, AML - acute Myeloid Leukemia, Magnesium Butyrate, acute myelogenousleukemia, Magnesium Butyrate., BUTANOIC ACID, acute non lymphoblastic leukemia, Myeloid, Butyrate, Butanoic Acid, butanic acid, Streptococcus faecium, Magnesium, Client, AML, CH3-[CH2]2-COOH, 1-butanoic acid, butoic acid, acute non lymphoblastic leukaemia, 1-butyric acid, Sodium, acute myeloid, Sodium Butyrate, aml1-evi-1, Butanoate, cbfa2, propylformic acid, evi-1, Runx-1, aml, Acute myelogenous leukemia, Acid, 1-propanecarboxylic acid, Leukemia, Butanoic acid, Magnesium Dibutyrate, Butyric, Myeloblastic, Xaml1, acide butanoique, Dibutyrate, Acute Myeloblastic Leukemia, susceptibility to, Butyric Acid, Acute Myeloid Leukemia, C4:0, amlcr1, pebp2ab, aml1, XAML, propanecarboxylic acid, Sodium Salt, Acute, Patient, n-butanoic acid, 4:0, Clients, Buttersaeure, aml-1, Butyric Acid Magnesium Salt, acide butyrique, ethylacetic acid, ANLL, Butanoic, n-butyric acid, acute myelogenousfalseNovel intestinal markers in newly diagnosed AML patients: Enterococcus faecium and butyric acidEnterococci, butyric acid have excellent diagnostic efficacy in acute myeloid leukemia.2024-09-102024-09-10PRJEB79919