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Sydeny, School of Medical Sciences","UNSW Sydeny, School of Biomedical Sciences"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB81782"],"long_description":["This study examined changes in gut microbiota composition prior to pregnancy, and across gestation and lactation in rat dams fed either a high-fat, high-sugar Cafeteria (Caf) diet or Chow. Microbiome development was assessed in their offspring weaned onto chow. Caf diet consumption during pregnancy increased weight gain and adiposity, but also lowered plasma folate and B12 levels which indicates metabolic disturbance in dams and implicates disruption of offspring development. α- and β diversity measures in Caf-fed dams showed a different trajectory across the progression of pregnancy, with no change in Bacteroidetes and Firmicutes abundance compared with Chow dams, who showed reduced Firmicutes at gestation and mid-lactation. Offspring born to Caf dams exhibited greater adiposity and plasma leptin at weaning (3 weeks) and 14 weeks of age than those born to Chow dams. Caf dam weanling had lower plasma folate but higher B12 levels compared with their counterparts. Maternal plasma folate levels were positively associated with maternal and weanling gut microbiota, specifically with OTU2 Romboutsia and OTU3_Lactobacillus relative abundance. Maternal Caf diet induced clear differences in β diversity in weanlings but not α diversity. SourceTracker analysis revealed similarities in the gut microbiota of Chow weanlings and maternal gut microbiota observed during lactation, whereas the microbiota of Caf weanlings was similar to the maternal gut microbiota during gestation. Maternal Caf diet exerted only marginal effects on gut microbiota composition in 14-week-old offspring consuming regular chow."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Altered gut microbiome in rat dams during pregnancy was disrupted by obesogenic diet","description":"Effect of obesogenic diet on materna gut microbiota during pregancy","dates":{"last_updated":"2025-04-30","first_public":"2025-04-30"},"accession":"PRJEB81782","cross_references":{}}