{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Hacettepe University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB83982"],"long_description":["Dedicator of cytokinesis protein 8 (DOCK8) is a guanine nucleotide exchange factor highly expressed in and critical for the function of various innate and adaptive immune cells. DOCK8 deficiency leads to combined immunodeficiency and a severe Th2-type immune response. We compared immune repertoire profiles determined by high-throughput TCR sequencing of circulating CD4+ and CD8+ T cells from patients with DOCK8 deficiency.Different diversity analyses revealed a restricted TRA and TRB repertoire in both CD4+ and CD8+ T cells from DOCK8-deficient patients."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Immune repertoire RNA-seq","description":"Comprehensive αβ T cell repertoire analysis reveals a unique CD8+ TCR landscape in DOCK8-deficient patients","dates":{"last_updated":"2025-05-31","first_public":"2025-05-31"},"accession":"PRJEB83982","cross_references":{}}