ENAapplication/xmlftp://primaryOK200GenomicsBROAD INSTITUTE, INC.https://www.ebi.ac.uk/ena/browser/view/PRJNA1002012Homo sapiensWe designed this study to examine the etiology of multiple lung tumors in EGFR-mutant non-small cell lung cancer patients who undergo surgical resection. Participants were 52-85 years old never or former smokers, who had at least 2 surgical lung tumor pathology specimens available in the Massachusetts General Hospital biobank, at least one of which had an EGFR mutation by routine clinical genotyping. 10 patients were selected, along with two patients from a family with an inherited EGFR-T790M mutation leading to multiple lung tumors. These patient tumor samples and matched normal lung samples were microdissected to collect DNA.In addition to obtaining clinical histories, we performed whole exome sequencing to evaluate the genetic profile of matched tumor and normal samples. The WES data... (for more see dbGaP study page.)ENADER/faint little ball, Lung, D-Egf, C-erb, Neoplasms, Elp-B1, der, lung cancer, Elp-1, mor1, Errb1, mENA, EK2-6, PIG61, Mutations, Germ Line, epidermal growth factor-activated receptor activity, AI552599, Germline, c-erbB, EGFr, Egfr, Germ-Line Mutations, torpedo/Egfr, EGF receptor activity, TOP, Egf-r, d-egf-r, Pulmonary Cancer, Pulmonary, Lung Cancer, Germline Mutations, EGF-R, alveolar cell carcinoma, LNCR, top, Torpedo/DER, Lung Cancers, flb, Germ-Line, top/flb, Lung Neoplasm, l(2)57EFa, Germline Mutation, 9030024J15Rik, D-EGFR, l(2)57Ea, NISBD2, DER1, Cancer, Elp-B1RB1, Pulmonary Neoplasms, Lung cancer, Elp, Wa5, l(2)09261, TGF-alpha receptor activity, ERBB, dEGFR1, DEgfr, Cancer of Lung, CG10079, torpedo/egfr, epidermal growth factor receptor activity, wa2, DmelCG10079, cancer of lung, Neoplasm, Nonsmall cell lung cancer, NOS, DER/top, Germ Line Mutation, Mutation, egfr, HD-33, El, top/DER, Pulmonary Neoplasm, DER/EGFR, EGFR, EGfr, EgfR, dEgfr, DER flb, ERBB1, Cancers, wa-2, Torpedo/Egfr, Degfr, Egf, EFG-R, Errp, Erbb, DEGFR, cancer of the lung, Pulmonary., l(2)57DEFa, l(2)05351, Der, DER, protection against, dEGFR, Pulmonary Cancers, transforming growth factor-alpha receptor activity, DmHD-33, lung neoplasm, Cancer of the Lung, DER/torpedo, HER1DER/faint little ball, Lung, D-Egf, C-erb, Neoplasms, Elp-B1, der, lung cancer, Elp-1, mor1, Errb1, mENA, EK2-6, PIG61, Mutations, Germ Line, epidermal growth factor-activated receptor activity, AI552599, Germline, c-erbB, EGFr, Egfr, Germ-Line Mutations, torpedo/Egfr, EGF receptor activity, TOP, Egf-r, d-egf-r, Pulmonary Cancer, Pulmonary, Lung Cancer, Germline Mutations, EGF-R, alveolar cell carcinoma, LNCR, top, Torpedo/DER, Lung Cancers, flb, Germ-Line, top/flb, Lung Neoplasm, l(2)57EFa, Germline Mutation, 9030024J15Rik, D-EGFR, l(2)57Ea, NISBD2, DER1, Cancer, Elp-B1RB1, Pulmonary Neoplasms, Lung cancer, Elp, Wa5, l(2)09261, TGF-alpha receptor activity, ERBB, dEGFR1, DEgfr, Cancer of Lung, CG10079, torpedo/egfr, epidermal growth factor receptor activity, wa2, DmelCG10079, cancer of lung, Neoplasm, Nonsmall cell lung cancer, NOS, DER/top, Germ Line Mutation, Mutation, egfr, HD-33, El, top/DER, Pulmonary Neoplasm, DER/EGFR, EGFR, EGfr, EgfR, dEgfr, DER flb, ERBB1, Cancers, wa-2, Torpedo/Egfr, Degfr, Egf, EFG-R, Errp, Erbb, DEGFR, cancer of the lung, Pulmonary., l(2)57DEFa, l(2)05351, Der, DER, protection against, dEGFR, Pulmonary Cancers, transforming growth factor-alpha receptor activity, DmHD-33, lung neoplasm, Cancer of the Lung, DER/torpedo, HER1falseGermline mutations and developmental mosaicism underlying EGFR-mutant lung cancerGermline mutations and developmental mosaicism underlying EGFR-mutant lung cancer2025-09-242023-09-02PRJNA10020129606