ENAGenomicsMultiomicsBenz Lab, Buck Institute of Age Researchhttps://www.ebi.ac.uk/ena/browser/view/PRJNA100413Homo sapiensSignaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. Keywords: biomarker identification Overall design: 54 ER+ node negative breast tumors with known clinical outcome were analyzed. Genes co-ordinately regulated by NFKB and AP1from literature are identified from a significant gene set obtained through a minimum variation filter. Biomarker expression is used to dichotomize samples into high vs. low expressors to determine prognostic valuexref:PubMed:18631401xref:PubMed:17407600ENAHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManHuman Mammary Neoplasm, Breast Carcinoma, primary breast cancer, Carcinoma, data, malignant tumor of the breast, breast tumour, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], RnBP, Breast Neoplasms, Neoplasms, GlcNAc 2-epimerase, mammary neoplasm, Mammary Cancers, Human Mammary Neoplasms, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], Human, Breast Malignant Neoplasm, Breast Malignant Tumor, N-acetyl-D-glucosamine 2-epimerase, tumor of the breast, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, BREAST NEOPL, RENBP, Neoplasm, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, neoplasm, Malignant Neoplasm of Breast, tumor of breast, Carcinomas, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Breast Neoplasm, tumour of the breast, NEOPL BREAST, Mammary Neoplasm, Mammary Carcinoma, Human Mammary Carcinomas, Cancers, breast neoplasm (disease), Breast Malignant Neoplasms., "mammary neoplasm" RELATED [], Cancer of the Breast, AGE, neoplasm of breast, tumour of breast, neoplasm of the breast, breast neoplasm, breast cancer, cancer of breast, Malignant Tumor of Breast, Mammary, Mammary Cancer, Breast Tumors, Breast Cancer, Breast Malignant Tumors, renin-binding protein, Cancer of Breast, Breast, mammary cancer, cancer, mammary tumor, breast, Tumors, CancerfalseHomo sapiensExpression data from age-dichotomized ER+, N0 breast tumors2025-09-242014-02-11PRJNA100413GSE737896061740760018631401