ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/069/SRR25688569/SRR25688569_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/077/SRR25688577/SRR25688577_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/073/SRR25688573/SRR25688573_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/070/SRR25688570/SRR25688570_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/079/SRR25688579/SRR25688579_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/074/SRR25688574/SRR25688574_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/074/SRR25688574/SRR25688574.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/069/SRR25688569/SRR25688569.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/080/SRR25688580/SRR25688580_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/078/SRR25688578/SRR25688578_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/069/SRR25688569/SRR25688569_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/077/SRR25688577/SRR25688577.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/071/SRR25688571/SRR25688571_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/072/SRR25688572/SRR25688572_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/075/SRR25688575/SRR25688575_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/074/SRR25688574/SRR25688574_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/075/SRR25688575/SRR25688575_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/079/SRR25688579/SRR25688579_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/077/SRR25688577/SRR25688577_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/076/SRR25688576/SRR25688576_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/073/SRR25688573/SRR25688573_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/080/SRR25688580/SRR25688580_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/076/SRR25688576/SRR25688576_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/078/SRR25688578/SRR25688578_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/071/SRR25688571/SRR25688571_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/070/SRR25688570/SRR25688570_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/072/SRR25688572/SRR25688572_1.fastq.gzprimary200OKGenomicsCardiology, Albert Einstein College of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA1006685Mus musculusOur study provides the first direct evidence supporting a fibroblast-mediated mechanism of dysfunction and adverse remodeling in the diabetic heart, highlighting the importance of interstitial cells in the pathogenesis of diabetic cardiomyopathy. Diabetes-associated activation of the TGF-b/Smad3 cascade may promote dysfunction not only by accentuating ECM deposition and crosslinking, but also by modulating cardiomyocyte phenotype and function. Thus, the TGF-b system may be a promising therapeutic target in patients with diabetes-associated heart failure. Overall design: Comparison of the transcriptomic profile of cardiac fibroblasts from Smad3KO vs. Smad3 lean and db/db animals. 3 samples per group (12 samples in total).xref:PubMed:39373248ENAfalseFibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb]Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb]2025-09-242024-08-26PRJNA1006685GSE2411761009039373248