ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/041/SRR25689241/SRR25689241_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/037/SRR25689237/SRR25689237_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/039/SRR25689239/SRR25689239_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/043/SRR25689243/SRR25689243_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/041/SRR25689241/SRR25689241_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/038/SRR25689238/SRR25689238_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/042/SRR25689242/SRR25689242_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/042/SRR25689242/SRR25689242_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/040/SRR25689240/SRR25689240_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/039/SRR25689239/SRR25689239_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/040/SRR25689240/SRR25689240_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/043/SRR25689243/SRR25689243_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/038/SRR25689238/SRR25689238_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/037/SRR25689237/SRR25689237_1.fastq.gzprimary200OKGenomicsCardiology, Albert Einstein College of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA1006686Mus musculusOur study provides the first direct evidence supporting a fibroblast-mediated mechanism of dysfunction and adverse remodeling in the diabetic heart, highlighting the importance of interstitial cells in the pathogenesis of diabetic cardiomyopathy. Diabetes-associated activation of the TGF-b/Smad3 cascade may promote dysfunction not only by accentuating ECM deposition and crosslinking, but also by modulating cardiomyocyte phenotype and function. Thus, the TGF-b system may be a promising therapeutic target in patients with diabetes-associated heart failure. Overall design: Comparison of the transcriptomic profile of cardiac fibroblasts stimulated by TSP-4 (3 samples) vs. control (4 samples).xref:PubMed:39373248ENAfalseFibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: TSP4 stimulation]Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: TSP4 stimulation]2025-09-242024-08-26PRJNA1006686GSE2411771009039373248