ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/083/SRR25688583/SRR25688583_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/085/SRR25688585/SRR25688585_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/087/SRR25688587/SRR25688587_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/081/SRR25688581/SRR25688581_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/085/SRR25688585/SRR25688585_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/082/SRR25688582/SRR25688582_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/083/SRR25688583/SRR25688583_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/086/SRR25688586/SRR25688586_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/088/SRR25688588/SRR25688588_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/084/SRR25688584/SRR25688584_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/082/SRR25688582/SRR25688582_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/086/SRR25688586/SRR25688586_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/088/SRR25688588/SRR25688588_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/084/SRR25688584/SRR25688584_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/081/SRR25688581/SRR25688581_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR256/087/SRR25688587/SRR25688587_2.fastq.gzprimary200OKGenomicsCardiology, Albert Einstein College of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA1006688Mus musculusxref:PubMed:39373248Our study provides the first direct evidence supporting a fibroblast-mediated mechanism of dysfunction and adverse remodeling in the diabetic heart, highlighting the importance of interstitial cells in the pathogenesis of diabetic cardiomyopathy. Diabetes-associated activation of the TGF-b/Smad3 cascade may promote dysfunction not only by accentuating ECM deposition and crosslinking, but also by modulating cardiomyocyte phenotype and function. Thus, the TGF-b system may be a promising therapeutic target in patients with diabetes-associated heart failure. Overall design: Comparison of the transcriptomic profile of cardiac fibroblasts with TSP-4 overexpression (4 samples) vs. control (4 samples).ENAfalseFibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: TSP4 OE]Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: TSP4 OE]2025-09-242024-08-26PRJNA1006688GSE2411781009039373248