{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Binqing Fu Lab, Life sciences and medicine, University of Science and Technology of China"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1021250"],"scientific_name":["Mus musculus"],"long_description":["Previous research indicate MIA propagates maternal inflammation to the fetal developing brain, that manifests as increased pro-inflammatory cytokines and activation of macrophages. Our data sugests that maternal Granzyme B released by aberrant decidual NK cells can reach to the fetal brain and instigate the activation of macrophages. To determine whether Gzmb can directly impact macrophages, we co-cultured murine microglial BV-2 cells with Gzmb for 20 hours, and then performed gene expression profiling analysis. We found that GzmB exposure directly induces a unique gene signature in microglia that includes the unexpected upregulation of multiple interferon-stimulated genes (ISGs). Overall design: Murine microglial BV2 cells were stimulated for 20 hours using different treatments, including Ctrl, GZMB (500 ng/ml), amniotic fluid (AF, 50 μl), and AF (50 μl) + GZMB (500 ng/ml)"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular Granzyme B directly drives Interferon-stimulated genes expression in macrophages.","description":"Extracellular Granzyme B directly drives Interferon-stimulated genes expression in macrophages.","dates":{"last_updated":"2025-09-24","first_public":"2025-08-02"},"accession":"PRJNA1021250","cross_references":{"GEO":["GSE244113"],"taxon":["10090"]}}