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Institute of Oriental Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA1024419Homo sapiensThis study aimed to identify transcript expression induced by tonifying herbal medicines (THM) and modes of action (MOA) of THM in A549 cell line. For the production of THM-induced transcripts, tonifying herbal medicines water extract (THW) and tonifying herbal medicines ethanol extract (THE) were used. Overall design: Comparative gene expression profiling analysis of RNA-seq data for THW (500 ug/mL, 100 ug/mL, and 20 ug/mL, respectively), THE (500 ug/mL, 100 ug/mL, and 20 ug/mL, respectively), positive control (wortmannin 10uM), and vehicle control (2% DMSO). However, in extracts with IC20 of less than 500ug/mL, the concentration at IC20 and the concentration diluted to 1/5 and 1/25 of the IC20 concentration were used, respectively. Please note that the RCM_tonifying_HepG2.txt contains processed data for all batch samples and the corresponding data column header is indicated in the sample description field.ENAfalseDigital transformation of herbal medicine: Conversion to biological entity data using tonifying herbal medicine-induced transcriptome sequencing_HepG2_batchBDigital transformation of herbal medicine: Conversion to biological entity data using tonifying herbal medicine-induced transcriptome sequencing_HepG2_batchB2025-09-242024-06-23PRJNA1024419GSE2447039606