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2023 Defining genetic diversity of rhesus macaque Fcg receptors with long-read RNA"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1030012"],"tag":["xref:EuropePMC:PMC10803544","xref:EuropePMC:PMC10732150"],"long_description":["Fc-gamma receptors are membrane-bound glycoproteins crucial for mediating immune responses through interactions with IgG antibodies. While human studies have linked Fc-gamma receptors gene polymorphisms to infection risk and disease progression, the understanding of Fc-gamma receptors genetic diversity in rhesus macaques, a key translational model for human health interventions, remains limited. This study employed long-read RNA sequencing to explore the genetic diversity of Fc-gamma receptors in 206 Indian-origin rhesus macaques, unveiling a variety of genetic variations. By indexing this genetic diversity using predicted and known rhesus macaque Fc-gamma receptors and Fc-Fc-gamma receptors structures, a foundation is laid for future studies. Understanding the functional significance of this genetic diversity will enhance the translation of antibody-mediated outcome studies performed in rhesus macaques to human applications."],"repository":["ENA"],"description_synonyms":["Genetic Variations, rhesus macaque, Rhesus Macaque, RNA, Variations, Macaque, RNA Sequence Determination, Macaca mulatta lasiotas, RNA Sequence Determinations, AP-1, Sequence Determination, RNA Sequence, AP1gamma, rhesus monkeys, Diversities, Light, gamma-Ada, Rhesus Monkeys, Determinations, Chinese Rhesus Macaque, read, cg9113, hnu, Genetic Diversities, Cercopithecus mulatta, Chinese Rhesus Macaques, Analysis, foton, dgamma, Rhesus Macaques, Diversity, Monkey, Genetic, CG9113, Analyses, Determination, Lichtquant, AP1gamma1, rhesus macaques, Genetic Diversity, Macaca mulatta lasiota, DmelCG9113, Sequence Determinations, Sequencing, light quantum, RNA Sequence Analyses, RNA Sequence Analysis, RNA., photon, Rhesus monkey, RNA Sequencing, Rhesus Monkey, Rhesus, AP-1[gamma], Chinese, Variation, gamma, Sequence Analyses"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Defining genetic diversity of rhesus macaque Fc-gamma receptors with long-read RNA sequencing","dates":{"last_updated":"2023-11-30","first_public":"2023-11-30"},"accession":"PRJNA1030012","cross_references":{}}