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We assessed the effect of hypertension and/or stroke on brain injury, cognitive outcome, and the brain transcriptomic profile. C57BL/6J mice (n=117 3-5 mo.) received s.c. infusion of either saline or angiotensin II (for 14 d or 28 d) followed by sham surgery or photothrombotic stroke targeting the prefrontal cortex seven days later. Cognitive function was assessed with the Barnes maze. RNA sequencing was used to quantify transcriptomic changes in the brain. Angiotensin II treatment produced spontaneous hemorrhaging on the stroke brain. In the Barnes maze, hypertensive mice that received stroke surgery had an increased escape latency compared to other groups (day 3: hypertensive + stroke=166.6±6.0 s vs. hypertensive + sham=122.8±13.8 s vs. normotensive + stroke=139.9±10.1 s vs. normotensive + sham=101.9±16.7 s), consistent with a greater learning impairment. RNA sequencing revealed >800 differentially expressed genes related to neuroinflammation in hypertensive + stroke vs. hypertensive + sham, which included genes associated with apoptosis, microRNAs, autophagy, anti-cognitive biomarkers and Wnt signaling. The combination of hypertension and stroke resulted in greater learning impairment and brain injury. Overall design: To investigate the concomittant effect of hypertension and stroke on the brain, prefrontal samples of the male mice brain were used to assess transcriptomic changes related to neuroinflammation."],"tag":["xref:PubMed:38886874"],"repository":["ENA"],"description_synonyms":["CVA (cerebral vascular accident), Brain, 3.4.22.-, Apoplexy, Cerebrovascular accidents, Intracranial hemorrhage, Strokes, Laboratory, CVA (Cerebrovascular Accident), Mus domesticus, mouse, mini-ICE, CASP-14, Unspecified intracranial hemorrhage, INTRACRANIAL HEMORR NOS, Cerebrovascular accident, Cerebrovascular Stroke, Hemorrhages, Cerebrovascular Apoplexy, House Mouse, Posterior Fossa Hemorrhage, Brain Vascular Accident, Acute Cerebrovascular Accident, Cerebrovascular Apoplexya, Acute Stroke, House, Mus, cerebrovascular accident, Mini-ICE, CVA, (CVA), Mus musculus domesticus, Vascular Accidents, NOS, cerebral infarction, Brain Hemorrhages, Cerebral, Cerebrovascular, Mice, SYNDROME, Cerebrovascular Accidents, Mus musculus., Phenomenography, Stroke/CVA - undefined, Mus musculus, Cerebral Stroke, HEMORRHAGE INTRACRANIAL, CVAs (Cerebrovascular Accident), Vascular Accident, Caspase-14 subunit p10, Stroke and cerebrovascular accident unspecified, Stroke NOS, Intracranial haemorrhage NOS, Swiss, Hemorrhage, mice, CVA - Cerebrovascular accident unspecified, Intracranial Hemorrhages, STROKE, Swiss Mouse, House Mice, Swiss Mice, Cerebrovascular Accident, Caspase-14 subunit p19, MICE, Intracranial Hemorrhage, Cerebral Strokes, Laboratory Mice, domesticus, Brain Vascular Accidents, Cerebrovascular Strokes, Intracranial hemorrhage (disorder), Intracranial, Stroke, Brain attack, Stroke NOS (disorder), Cerebrovascular accident (disorder), Acute Strokes, Acute, Stroke and cerebrovascular accident unspecified (disorder), stroke, intracranial hemorrhage NOS (disorder), Posterior Fossa Hemorrhages, Mouse, Acute Cerebrovascular Accidents, Laboratory Mouse, Cerebrovascular accident (disorder) [Ambiguous], CEREBROVASCULAR ACCIDENT, Posterior Fossa, Intracranial haemorrhage, Brain Hemorrhage"],"name_synonyms":["CVA (cerebral vascular accident), Brain, 3.4.22.-, Apoplexy, Cerebrovascular accidents, Intracranial hemorrhage, Strokes, Laboratory, CVA (Cerebrovascular Accident), Mus domesticus, mouse, mini-ICE, CASP-14, Unspecified intracranial hemorrhage, INTRACRANIAL HEMORR NOS, Cerebrovascular accident, Cerebrovascular Stroke, Hemorrhages, Cerebrovascular Apoplexy, House Mouse, Posterior Fossa Hemorrhage, Brain Vascular Accident, Acute Cerebrovascular Accident, Cerebrovascular Apoplexya, Acute Stroke, House, Mus, cerebrovascular accident, Mini-ICE, CVA, (CVA), Mus musculus domesticus, Vascular Accidents, NOS, cerebral infarction, Brain Hemorrhages, Cerebral, Cerebrovascular, Mice, SYNDROME, Cerebrovascular Accidents, Mus musculus., Phenomenography, Stroke/CVA - undefined, Mus musculus, Cerebral Stroke, HEMORRHAGE INTRACRANIAL, CVAs (Cerebrovascular Accident), Vascular Accident, Caspase-14 subunit p10, Stroke and cerebrovascular accident unspecified, Stroke NOS, Intracranial haemorrhage NOS, Swiss, Hemorrhage, mice, CVA - Cerebrovascular accident unspecified, Intracranial Hemorrhages, STROKE, Swiss Mouse, House Mice, Swiss Mice, Cerebrovascular Accident, Caspase-14 subunit p19, MICE, Intracranial Hemorrhage, Cerebral Strokes, Laboratory Mice, domesticus, Brain Vascular Accidents, Cerebrovascular Strokes, Intracranial hemorrhage (disorder), Intracranial, Stroke, Brain attack, Stroke NOS (disorder), Cerebrovascular accident (disorder), Acute Strokes, Acute, Stroke and cerebrovascular accident unspecified (disorder), stroke, intracranial hemorrhage NOS (disorder), Posterior Fossa Hemorrhages, Mouse, Acute Cerebrovascular Accidents, Laboratory Mouse, Cerebrovascular accident (disorder) [Ambiguous], CEREBROVASCULAR ACCIDENT, Posterior Fossa, Intracranial haemorrhage, Brain Hemorrhage"],"additional_accession":[]},"is_claimable":false,"name":"Post-Stroke Learning Impairment and Brain Hemorrhage are Augmented in Hypertensive Mice","description":"Post-Stroke Learning Impairment and Brain Hemorrhage are Augmented in Hypertensive Mice","dates":{"last_updated":"2025-09-24","first_public":"2024-11-29"},"accession":"PRJNA1040322","cross_references":{"GEO":["GSE247789"],"taxon":["10090"],"PubMed":["38886874"]}}