ENAGenomicsKeio University School of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA1053421Mus musculusWe identified an autoantibody (IgGr22) directly involved in the development of sialadenitis. IgGr22 was found to promote the proliferation of pathogenic T cells. IgGr22 specifically recognized double-stranded RNA (dsRNA) and induced the activation of dendritic cells, thereby enhancing the expression of IFN signature and inflammatory genes. Overall design: CD45+ cells were isolated from the salivary glands of Rag-/- mice transferred with pathogenic CD4+ T cells and recombinant autoantibody (IgGr22) related to Sjögren's syndrome using fluorescence-activated cell sorting (FACS).ENAfalseIdentification of an autoantibody promoting the development of Sjögren's Syndrome-like sialadenitisIdentification of an autoantibody promoting the development of Sjögren's Syndrome-like sialadenitis2025-09-242025-09-08PRJNA1053421GSE25036910090