ENAGenomicsBeijing Institute of Genomics Chinese Acad of Sci - Key Labhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1057354Oryza sativaEpigenetic pathways could provide a mechanistic explanation for the inheritance of acquired characteristics (IAC). However, epigenetic alterations that endow adaptive hereditary traits have rarely been observed. Here, we identified an epiallele conferring acquired and heritable cold tolerance, an adaptive trait enabling the northward spread of rice. We subjected cold-sensitive rice to multigenerational cold stress and identified a line with acquired stable inheritance of cold tolerance. DNA hypomethylation variation in the Acquired Cold Tolerance 1 (ACT1) gene rendered its expression insensitive to cold. Raw data used are deposited here.ENAInheritance, T22F8.160, and rna binding 2, DISEASE (COPD), Chronic Airflow Obstructions, CAO - Chronic airflow obstruction, chronic obstructive pulmonary disease (COPD), circadian rhythm, CHRONIC OBSTRUCTIVE PULM DIS, DNA Methylations, Chronic obstructive pulmonary disease NOS, and RNA binding 1, Chronic obstructive pulmonary disease finding, Cold, PULMONARY DISEASE (COPD), Pulmonary Disease, T22F8_160, ATGPR7, Rices, chronic obstructive airways disease NOS (disorder), Chronic irreversible airway obstruction, GRP8, GRP7, Chronic Obstructive Pulmonary Disease (COPD), DNA., Cold Temperatures, COLD (chronic obstructive lung disease), DNA methylation maintenance, NEC in ICD9CM_2006, CAFL - Chronic airflow limitation, DNA methylation, Chronic Obstructive, Chronic airflow limitation, ATGRP7, disease (COPD), GLYCINE RICH PROTEIN 7, ATGRP8, NEC, Chronic, glycine-rich RNA-binding protein 8, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Methylations, Asian cultivated rice, COPD, CHRONIC, COAD - Chronic obstructive airways disease, chronic obstructive lung disease [Ambiguous], obstructive lung disease, chronic obstructive airways disease NOS, not elsewhere classified, COAD, COLD - Chronic obstructive lung disease, not genetically inherited, chronic, PULM DIS CHRONIC OBSTRUCTIVE, Airflow Obstructions, Chronic obstructive pulmonary disease finding (finding), CHRONIC OBSTRUCTIVE AIRWAY DIS, pulmonary disease (COPD), Temperatures, CHRONIC OBSTRUCTIVE, chronic obstructive pulmonary disease and allied conditions, red rice, Chronic airway disease, NOS, GLYCINE-RICH RNA-BINDING PROTEIN 7, (COPD), chronic airway obstruction, Airflow Obstruction, chronic obstructive, CAL - Chronic airflow limitation, COPD NOS, CHRONIC OBSTRUCTIVE LUNG DIS, chronic obstructive airway disease, GLYCINE-RICH PROTEIN 8, Chronic Obstructive Airways Disease, Temperature, Chronic airway obstruction, Chronic obstructive lung disease, cold, Dops, GR-RBP7, Oryza sativa, GR-RBP8, Rice, Chronic Airflow Obstruction, red rice <Oryza sativa>, F2G1.4, OBSTRUCTIVE PULMONARY DISEASE (COPD), COPD - Chronic obstructive pulmonary disease, rice, chronic obstructive lung disease (disorder), chronic obstructive airways disease, cold (chronic obstructive lung disease), Chronic Obstructive Lung Disease, obstructive pulmonary disease (COPD), DNA, chronic obstructive lung disease, COLD, Methylation, chronic obstructive pulmonary diseasered rice, Oryza sativa, Rice., red rice <Oryza sativa>, rice, Asian cultivated rice, RicesfalseOryza sativaInheritance of acquired adaptive cold tolerance in rice through DNA methylation2025-09-242023-12-28PRJNA10573544530