ENAGenomics318, Biomedicine, Universityhospital of Baselhttps://www.ebi.ac.uk/ena/browser/view/PRJNA107201Mus musculusxref:PubMed:18388181We have cloned and characterized a fusion gene NUP98/HHEX1 resulting from t(7 10) from a patient with acute myeloid leukemia (AML). As NUP98/HHEX acts as an aberrant transcriptional activator, putative targets were searched upon transient expression of the fusion in primary murine bone marrow cells. Keywords: Comparative analysis of NUP98/HHEX, NUP98/HOX vs. MIG (empty virus) in primary bone marrow cells Overall design: Murine bone marrow cells were transduced with a retrovirus (MSCV-IRES-GFP, MIG) expressing either NUP98/HHEX or NUP98/HOXA9 (or the empty vector), mRNA was isolated after 72h. Each experiment was performed in triplicates.ENAMyelogenous Leukemias, Myelocytic, Acute Myeloblastic, acute myeloblastic leukemia, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, acute myeloblastic leukaemia, acute myelogenous leukaemia, nup145, Myelocytic Leukemia, hex, Acute Myeloid, Acute Myelocytic Leukemias, nup96, acute non lymphoblastic leukaemia, M1., nup98, Nucleoporin Nup96, Acute Myelocytic, Acute Nonlymphoblastic, tHex, Nucleoporin Nup98, NUP96, acute myeloid, nucleoporin, NUP98, Myeloblastic Leukemia, 98 kDa nucleoporin, Leukemia, l(3)95BCd, Acute Myelogenous, Acute Myeloblastic Leukemia, nup189C, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, Acute Myeloid Leukemia without Maturation, CG10201, Acute Nonlymphoblastic Leukemia, Acute Nonlymphocytic Leukemia, Myeloid Leukemia, Myelocytic Leukemias, nup189N, ANLL, Nup98/96, Nonlymphoblastic Leukemias, Nup98-Nup96, acute myelogenous, leukemia, Myelogenous, M1, M2, PRH, Prh, Nup 98, acute myelogenous leukemia, Nup 96, XHex, Prhx, ADIR2, HMPH, Leukemias, CG10198, AML, AI849286, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, Nonlymphoblastic, HOX11L-PEN, Acute Myeloid Leukemias, DmelCG10198, Myeloid Leukemias, Hex1, PRHX, Acute Nonlymphocytic, Nup-98, Acute Myelogenous Leukemia, acute, Acute myelogenous leukemia, Nup96, hhex-A, Nup98, 4732457F17, Myeloblastic, susceptibility to, Myeloblastic Leukemias, Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, Nonlymphocytic, Acute Myeloid Leukemia with Maturation, Nuclear pore complex protein Nup96, Acute, Nuclear pore complex protein Nup98, NUP196, Acute Nonlymphoblastic Leukemias, Acute Myeloblastic Leukemias, 96 kDa nucleoporin, Acute Myelogenous Leukemias, Hhex-rs2, nup98-96, HEX, Hex, AML - acute Myeloid LeukemiaMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusNUP98/HHEX a new oncogenic fusion with acute myeloid leukemia2025-09-242014-02-11PRJNA107201GSE109091009018388181