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k/vol1/fastq/SRR280/079/SRR28015479/SRR28015479_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/023/SRR28227523/SRR28227523_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/035/SRR28245535/SRR28245535_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/004/SRR28230104/SRR28230104_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/053/SRR28245553/SRR28245553_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/002/SRR28245502/SRR28245502_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/020/SRR28245520/SRR28245520_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/008/SRR28245508/SRR28245508_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/011/SRR28245511/SRR28245511_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR282/017/SRR28245517/SRR28245517_1.fastq.gzprimary200OKGenomicsArizona State Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1078389SARS-CoV-2, the etiological agent of the Coronavirus Disease 2019, has had broad impacts on health. However, the impact of SARS-CoV-2 on the nasopharyngeal microbiome is not fully characterized, with many disagreements between studies. Furthermore, the interplay between SARS-CoV-2 and other viral diseases such as HIV is not well characterized. The purpose of this study is to analyze the relationship between the nasopharyngeal microbiome and SARS-CoV-2 in women living with HIV and their HIV-exposed unaffected (HEU) infants, as well as HIV-uninfected women and their HIV-unexposed unaffected women (HUU). We performed metagenomic sequencing of the bacterial microbiome in nasopharyngeal specimens collected longitudinally from Mathare, Kenya over a 8 month period. Characterizing the nasopharyngeal microbiome during SARS-CoV-2 infected and mediated HIV infection may identify bacteria implicated in SARS-CoV-2 dysbiosis or protection of the microbiome upon viral infection.ENAfalseNasopharyngeal microbiome in SARS-CoV-2 infected women and infants2024-07-242024-05-11PRJNA1078389