ENAGenomicsNeurological Sciences, University of Milanhttps://www.ebi.ac.uk/ena/browser/view/PRJNA108289Mus musculusSpinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Keywords: Comparative Gene Expression Analysis Overall design: The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.xref:PubMed:18769634ENABCD541, Amyotrophies, GEMIN1, SMNT, determination, Progressive Muscular, Progressive Muscular Atrophy, Continuous Wave Lasers, Neuronopathy, Scapuloperoneal Form of Spinal Muscular Atrophy, Q Switched Lasers, Adult Onset Spinal Muscular Atrophy, Gene, Lasers, Spinal Muscular, light amplification by the stimulated emission of radiation, Myelopathic Muscular, Muscular Atrophies, Oculopharyngeal Spinal Muscular Atrophy, Myelopathic, SMA, Pulsed, chemical analysis, Progressive, Proximal Myelopathic Muscular Atrophy, Hereditary Motor Neuronopathies, Neurogenic Scapuloperoneal, Myelopathic Muscular Atrophy, Motor Neuronopathies, SMN, Masers, Adult Spinal Muscular Atrophy, Motor Neuronopathy, Oculopharyngeal, Atrophies, Progressive Proximal Myelopathic Muscular Atrophy, Q-Switched Laser, T-BCD541, Muscular Atrophy, Maser, Gene Expressions, Pulsed Lasers, Scapuloperoneal Form, SMA3, SMA4, Spinal Muscular Atrophy, Adult-Onset Spinal Muscular Atrophy, SMA1, New England Type, SMA2, Progressive Muscular Atrophies, Scapuloperoneal Spinal Muscular Atrophy, Atrophy, Spinal Amyotrophy, Spinal Amyotrophies, Neuronopathies, Pulsed Laser, Bulbospinal, spinal muscular atrophy, Expressions, Bulbospinal Neuronopathy, Continuous Wave, SMA@., Distal Spinal Muscular Atrophy, TDRD16A, Continuous Wave Laser, Bulbospinal Neuronopathies, Q-Switched Lasers, Amyotrophy, Q-Switched, Hereditary Motor, Scapuloperoneal, Hereditary, Hereditary Motor Neuronopathy, Spinal, Expression, assay, Distal, Laser, Progressive Myelopathic Muscular Atrophy, Adult SpinalMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusGene Expression Analysis of laser-microdissected motorneurons in Spinal Muscular Atrophy (SMA)2025-09-242014-02-11PRJNA108289GSE102241009018769634