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However, the effects of long-term paternal use of donepezil on offspring are not clear. In this study, male rats were mated after 21 days of oral donepezil treatment to produce F1 offspring. We found that both male and female F1 offspring showed behavioral improvements in learning and memory, but no significant effects were observed on tests relevant to anxiety and depression. Significant transcriptomic changes were found in synaptic signaling pathways in hippocampal tissue of the F1 generation. In conclusion, our current findings suggest that long-term paternal exposure to donepezil may improve offspring learning and memory. Further investigation is warranted to fully elucidate other potential transgenerational effects.</long_description><repository>ENA</repository></additional><is_claimable>false</is_claimable><name></name><description>Paternal Preconceptional Donepezil Exposure Enhances Learning in Offspring</description><dates><last_updated>2025-04-05</last_updated><first_public>2025-04-05</first_public></dates><accession>PRJNA1093504</accession><cross_references/></HashMap>