{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Huazhong Agricultural University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1094887"],"long_description":["African swine fever (ASF) is a highly pathogenic disease caused by the African swine fever virus (ASFV), with nearly 100% mortality in domestic pigs, threatening the global swine industry, animal warfare, and food safety. However, no effective drug or vaccine is currently available to prevent ASFV infection. Here, by glycan microarray screening of ASFV protein glycan interactions, we discovered the recombinant ectodomain of CD2v, an outer envelope protein of ASFV, bound lambda carrageenan, a natural sulfated polysaccharide, and found the interaction between lambda carrageenan and CD2v affected the hemadsorption of ASFV. Moreover, we show that lambda carrageenan has activity in inhibiting ASFV infection of PAMs during the attachment and entry stages and could suppress the viral protein synthesizing and viral factory formation by inducing NF kappa B mediated proinflammatory factor production. Our results indicate lambda carrageenan is a potent anti-ASFV compound."],"repository":["ENA"],"description_synonyms":["Viral Factory, Positive Strand RNA Virus Replication-Transcription Complexes, Replication-Transcription Compartments, Virus Induced Double Membrane Vesicles, Viral Factories, Viral, Viral Replication Compartment, multicellular organismal biosynthetic process., Coronavirus Replication-Transcription Compartments, Viroplasm, kappa Carrageenan, lambda Carrageenan, Vesicles, biosynthesis, Virus-Induced Double-Membrane Vesicle, Virus Replication Centers, virus factory, lambda-Carrageenan, Vesicle, Carrageenin, Coronavirus RTCs, Virogenic Stroma, Coronavirus Replication Transcription Complexes, Virus Replication Compartment, Replication-Transcription Compartment, Viral Replication Centers, Virus, Coronavirus Double-Membrane Vesicle, Coronavirus, Double Membrane Vesicles, Coronavirus Replication-Transcription Compartment, Double-Membrane Vesicles, Coronavirus Replication-Transcription Complexes, Double-Membrane Vesicle, kappa-Carrageenan, Positive Strand RNA Virus Replication Transcription Complexes, Virus-Induced Double-Membrane Vesicles, single-organism biosynthetic process, Replication Compartment, Replication Center, Complexe, formation, Viral Replication Center, anabolism, Coronavirus Double-Membrane Vesicles, Virus-Induced, Replication-Transcription Complexes, Replication Centers, iota-Carrageenan, synthesis, Coronavirus Double-Membrane, Coronavirus Double Membrane Vesicles, Virus-Induced Double-Membrane, Coronavirus RTC, Coronavirus Replication Transcription Compartments, Virus Induced, Positive-Strand RNA Virus Replication-Transcription Compartments, Positive Strand RNA Virus Replication Transcription Compartments, Complexes, Replication Compartments, Zippered Endoplasmic Reticulum Double Membrane Spherules, Coronavirus Replication-Transcription, Virus Factories, Virus Replication Compartments, Zippered Endoplasmic Reticulum Double-Membrane Spherules, iota Carrageenan, Virus Factory, Virus Replication Center"],"additional_accession":[]},"is_claimable":false,"name":"","description":"The mechanisms of lambda carrageenan against ASFV viral factory formation","dates":{"last_updated":"2024-05-11","first_public":"2024-05-11"},"accession":"PRJNA1094887","cross_references":{}}