ENAGenomicsMolecular Medicine, Orthopedic Surgery, Rush University Medical Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA109725Mus musculusxref:PubMed:19519881Rheumatoid arthritis (RA) usually begins in females in their 4th-5th decade, suggesting that the aging of the immune system (immunosenescence) has a major impact on this disease. In the present microarray study, we set out to identify age- and arthritis-related gene expression pattern changes in proteoglycan (aggrecan)-induced arthritis (PGIA) model. Keywords: disease state analysis Overall design: We compared the gene expression profile of spleens from PG-immunized but non-arthritic old (older than 4 months) and young (1 month old) mice, and then made a comparison between non-arthritic and age-matched arthritic mice.ENA3.4.22.-, Arthritides, Laboratory, RnBP, Joint inflammation, Mus domesticus, CASP14, mouse, GlcNAc 2-epimerase, mini-ICE, CASP-14, "Arthritis (finding)" EXACT [SNOMEDCT_2005_07_31:372091005], "Arthritis (disorder)" EXACT [SNOMEDCT_2005_07_31:3723001], "arthritis" EXACT [CSP2005:2715-1134], House Mouse, "arthritis" EXACT [NCI2004_11_17:C2883], N-acetyl-D-glucosamine 2-epimerase, Oligoarthritis, House, Mus, Polyarthritides, RENBP, Mini-ICE, Mus musculus domesticus, BALB/cJ, "Inflammation of joint NOS" EXACT [MTHICD9_2006:716.9], Mice, "Inflammatory disorder of joint" EXACT [SNOMEDCT_2005_07_31:363178003], Mus musculus., Mus musculus, susceptibility, C, inflammatory disorder of joint, Oligoarthritides, Caspase-14 subunit p10, Arthritis, Swiss, mice, BALBc, Swiss Mouse, House Mice, Swiss Mice, Caspase-14 subunit p19, MICE, AGE, Laboratory Mice, domesticus, renin-binding protein, Mouse, Polyarthritis, Laboratory MouseMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusEffect of age on the arthritis susceptibility of BALB/c mice2025-09-242014-02-11PRJNA109725GSE131481009019519881