{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":[""]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"strain":["M19736"],"omics_type":["Genomics"],"center_name":["Antibiotic Resistance Mechanisms Research Laboratory"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1102182"],"scientific_name":["Escherichia coli"],"tag":["pathogen:priority","pathogen:bacterium","xref:EuropePMC:PMC11089171","pathogen"],"long_description":["In the present study, we wonder about the ability of E. coli M19736 clinical strain belonging to sporadic clone ST615 that was one of the first isolates harboring the mcr-1 gene in Latin America , to adapt to XDR phenotype by conjugation and transformation assays. The conservation along time of ARG in evolved MDR and XDR-E. coli M19736 strains showed different patterns of maintenance as well as variability in the capacity to transfer in turn the acquired conjugative plasmids including co-transfer of different plasmids. In addition, we identified EV in the native and in the evolved XDR-E. coli M19736 strains with crucial content for the competence of Antimicrobial resistance in the nosocomial niche, including the blaCTX-M-15 gene though the pDCAG1-CTX-M-15 was previously lost. As a whole, this scenario reveals the relevant role of sporadic clones as common vectors for the dissemination of acquired antimicrobial resistance within the framework of the HGT processes."],"classification":["bacteria"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Escherichia coli strain:M19736","description":"Escherichia coli strain:M19736 Genome sequencing","dates":{"last_updated":"2025-09-24","first_public":"2024-04-23"},"accession":"PRJNA1102182","cross_references":{"taxon":["562"]}}