ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/080/SRR29525080/SRR29525080_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/076/SRR29525076/SRR29525076_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/078/SRR29525078/SRR29525078_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/077/SRR29525077/SRR29525077_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/076/SRR29525076/SRR29525076_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/079/SRR29525079/SRR29525079_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/079/SRR29525079/SRR29525079_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/075/SRR29525075/SRR29525075_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/077/SRR29525077/SRR29525077_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/078/SRR29525078/SRR29525078_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/075/SRR29525075/SRR29525075_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR295/080/SRR29525080/SRR29525080_1.fastq.gzprimaryOK200Genomicsyangzhou universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1127666Homo sapiensxref:PubMed:39667501Via analyzing the expression matrix of palbociclib-sensitive and palbociclib-resistant tumors from patients with breast cancer, it was revealed that NSRP1 is associated with CDK4/6i resistance. Therefore, RNA Sequencing is performed for MCF7 cells transfected with ctr or NSRP1 siRNA to study the molecular mechanism of NSRP1 in mediating CDK4/6i resistance in breast cancer cells. Overall design: We transfected MCF7 cells with NSRP1 siRNAs or control siRNA.ENAfalseDownregulation of NSRP1 confers CDK4/6i resistance in breast cancer via activation of the IFN signaling pathwayDownregulation of NSRP1 confers CDK4/6i resistance in breast cancer via activation of the IFN signaling pathway2025-09-242025-01-31PRJNA1127666GSE270673960639667501