ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/049/SRR29618449/SRR29618449_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/039/SRR29618439/SRR29618439_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/047/SRR29618447/SRR29618447_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/036/SRR29618436/SRR29618436_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/035/SRR29618435/SRR29618435_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/044/SRR29618444/SRR29618444_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/049/SRR29618449/SRR29618449_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/036/SRR29618436/SRR29618436_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/046/SRR29618446/SRR29618446_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/040/SRR29618440/SRR29618440_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/046/SRR29618446/SRR29618446_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/044/SRR29618444/SRR29618444_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/040/SRR29618440/SRR29618440_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/039/SRR29618439/SRR29618439_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/047/SRR29618447/SRR29618447_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR296/035/SRR29618435/SRR29618435_2.fastq.gzftp://primary200OKGenomicsNew York University School of Medicine (NYU)https://www.ebi.ac.uk/ena/browser/view/PRJNA1129102Iron-sulfur clusters (ISCs) are cell-essential cofactors present in ~60 proteins including subunits of OXPHOS complexes I-III, DNA polymerases, and iron-sensing proteins. Dysfunctions in ISC biosynthesis are associated with anemias, neurodegenerative disorders, and metabolic diseases.To assess consequences of acute Iron-Sulfur cluster (ISC) inhibition in a whole body setting, we developed a mouse model in which key ISC biosynthetic enzyme NFS1 can be acutely and reversibly suppressed.ENAfalseNFS1 inhibition in mice2025-06-292025-06-29PRJNA1129102