ENAGenomicsLeukaemia Biology Laboratory, Cancer Research UK Manchester Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJNA114579Mus musculusxref:PubMed:19200802Leukemia cells from mice with MLL-AF10 AML were fractionated into separate sub-populations on the basis of c-kit expression, which correlates with MLL LSC frequency (Somervaille and Cleary, 2006). The sorted AML sub-populations exhibited substantial differences in their frequencies of AML CFCs/LSCs (mean 14-fold) and morphologic features, consistent with a leukemia cell hierarchy with maturation through to terminally differentiated neutrophils. Overall design: Leukemic splenocytes from four mice with MLL-AF10 AML were sub-fractionated in to c-kit high and c-kit negative sub-populations by FACS.ENAfalseMus musculusExpression profiling of MLL-AF10 myeloid leukemia cellular subsets2025-09-242014-02-11PRJNA114579GSE136921009019200802