{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/011/SRR30290211/SRR30290211_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/010/SRR30290210/SRR30290210_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/008/SRR30290208/SRR30290208_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/009/SRR30290209/SRR30290209_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/010/SRR30290210/SRR30290210_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/011/SRR30290211/SRR30290211_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/009/SRR30290209/SRR30290209_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR302/008/SRR30290208/SRR30290208_1.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Central South University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1149346"],"long_description":["We reveal a negative association between Human Papillomavirus (HPV)-encoded circular RNA, circE7, and the infiltration of CD8+ T cells in head and neck squamous cell carcinoma (HNSCC). Both in vitro and in vivo experiments demonstrate that circE7 suppresses the function and activity of T cells by downregulating the transcription of LGALS9, which encodes the galectin-9 protein. The molecular mechanism involves circE7 binding to acetyl-CoA carboxylase 1 (ACC1), promoting its dephosphorylation and thereby activating ACC1. Activated ACC1 reduces H3K27 acetylation at the LGALS9 gene promoter, leading to decreased galectin-9 expression. Notably, galectin-9 interacts with immune checkpoint molecules TIM-3 and PD-1, inhibiting the secretion of cytotoxic cytokines by T cells and promoting T cell apoptosis. Here, we demonstrate a mechanism by which HPV promotes immune evasion in HNSCC through a circE7-driven epigenetic modification, and propose a potential immunotherapy strategy for HNSCC that involves the combined use of anti-PD-1 and anti-TIM-3 inhibitors."],"repository":["ENA"],"description_synonyms":["circRNAs, Carcinoma, RNA, Squamous Cell Carcinoma of the Mouth, Squamous Cell Carcinoma of the Nasal Cavity, HPV Human Papillomaviruses, passive evasion of immune response of other organism involved in symbiotic interaction, Squamous Cell Carcinoma of the Head and Neck, Evasion, Head And Neck, Human Papilloma Viruses, Circular RNAs, Squamous Cell Carcinoma, Human, Hypopharyngeal Squamous Cell Carcinoma, Papilloma Virus, circRNA, mitigation of host immune response by virus, mitigation by virus of host immune response, RNAs, Immune Evasions, Human Papillomaviruses, passive immune evasion, Virus, Circular, passive evasion of host immune response, Oral Squamous Cell Carcinoma, immune evasion, HNSCC, Human Papilloma, Human Papilloma Virus, Papillomavirus Virus, HPV Human Papillomavirus, Oropharyngeal Squamous Cell Carcinoma, suppression by virus of host immune response, Human Papillomavirus Virus, Intronic RNA, HPV, Laryngeal Squamous Cell Carcinoma, Human papillomavirus, carcinoma of the head and neck, Oral Tongue Squamous Cell Carcinoma, human papillomavirus HPV, Head And Neck Squamous Cell Carcinomas, Oral Squamous Cell Carcinomas, evasion by virus of host immune response, Squamous Cell Carcinoma of the Larynx., mitigation of host immune response, Immune, Oral Cavity Squamous Cell Carcinoma, Circular Intronic, Squamous Cell Carcinoma of Larynx, Human Papillomavirus Viruses, Closed Circular, Evasions, Head and Neck Squamous Cell Carcinoma, Circular Intronic RNA, Closed, Squamous Cell of Head and Neck, Circular RNA, Human Papillomavirus, ciRNA, Closed Circular RNA, active evasion of host immune response"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Human Papillomavirus-encoded Circular RNA circE7 Promotes Immune Evasion in Head and Neck Squamous Cell Carcinoma","dates":{"last_updated":"2024-08-26","first_public":"2024-08-26"},"accession":"PRJNA1149346","cross_references":{}}