ENAGenomicsSingapore Immunology Networkhttps://www.ebi.ac.uk/ena/browser/view/PRJNA115467Homo sapiensIschemia exists in many diseased tissues including arthritic joints, atherosclerotic plaques and malignant tumors. Macrophages accumulate in these sites and upregulate genes in response to the hypoxia present. We used Illumina beadarrays to investigate the effect of hypoxia (18h at 0.1% oxygen) on gene expression by human monocyte-derived macrophages in vitro. Overall design: Primary macrophages were differentiated for 7 days in vitro from human peripheral blood (monocyte-derived macrophages, MDMs) and were subjected to severe hypoxia (< 0.1% O2) or normoxia (20.9% O2) in 5% CO2 humidified multi-gas incubators. Two replicates per condition. The supplementary file 'GSE16099_non-normalized_data.txt' contains non-normalized (raw) data for Samples GSM402885-GSM402888.ENAhuman being, Gene Expressions, Man (Taxonomy), Monocyte Derived Macrophages, Macrophages, Modern, Deficiencies, Hypoxemia, Gene, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, Monocyte Derived, Expressions, man, human, Human, Oxygen Deficiency, Oxygen Deficiencies, Bone Marrow-Derived, Monocyte-Derived Macrophage., Oxygen, Anoxia, Monocyte-Derived, Deficiency, Homo sapiens, Modern Man, Bone Marrow-Derived Macrophages, Expression, Anoxemia, Hypoxia, Man, Monocyte-Derived Macrophages, MacrophageHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensEffect of hypoxia on gene expression by human macrophages2025-09-242014-02-11PRJNA115467GSE160999606