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of Genetics and Developmental Biology, Chinese Academy of Scienceshttps://www.ebi.ac.uk/ena/browser/view/PRJNA1157322Mus musculusOver recent decades, research has established the hypothalamus, particularly the arcuate nucleus, as a central hub for the homeostatic control of energy balance. The hypothalamic arcuate nucleus is a pivotal regulator of energy balance, containing anorexic proopiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons, which exert opposing effects on energy homeostasis. However, the molecular identity of “non-AgRP, non-POMC” neurons remains unclear. We identified a distinct neuronal subtype characterized by the absence of Agrp and Pomc expressions, while exhibiting robust Crabp1 expression. Overall design: The hypothalamic arcuate nucleus of adult mice was microdissected for single-nucleus RNA sequencing.ENAnuclei, Nucleus, neuronal nucleus, nucleus atomi, Infundibular, noyau atomique, Transcriptome, Arcuate, Transcriptome Profile, Infundibular Nucleus, nucleus of CNS, nucleo, noyau, Profile, Expression Profiles, Gene Expression Profile, Gene, Kern, nucleus of neuraxis, Profiles, Hypothalamus Arcuate Nucleus, neuraxis nucleus, Atomkern, Signatures, whole transcriptome, Gene Expression, nucleus, Expression Signature, nervous system nucleus, Gene Expression Profiles, Expression Signatures, horsetail nucleus, Gene Expression Signatures, Arcuate Nucleus., Transcriptomes, cell nucleus, Gene Expression Signature, Signature, nucleo atomico, Expression Profile, Transcriptome Profilesnuclei, Nucleus, neuronal nucleus, nucleus atomi, Infundibular, noyau atomique, Transcriptome, Arcuate, Transcriptome Profile, Infundibular Nucleus, nucleus of CNS, nucleo, noyau, Profile, Expression Profiles, Gene Expression Profile, Gene, Kern, nucleus of neuraxis, Profiles, Hypothalamus Arcuate Nucleus, neuraxis nucleus, Atomkern, Signatures, whole transcriptome, Gene Expression, nucleus, Expression Signature, nervous system nucleus, Gene Expression Profiles, Expression Signatures, horsetail nucleus, Gene Expression Signatures, Arcuate Nucleus., Transcriptomes, cell nucleus, Gene Expression Signature, Signature, nucleo atomico, Expression Profile, Transcriptome ProfilesfalseSingle-nucleus transcriptome sequencing reveals a specific neuronal subtype in the arcuate nucleus.Single-nucleus transcriptome sequencing reveals a specific neuronal subtype in the arcuate nucleus.2025-09-242024-12-12PRJNA1157322GSE27641410090