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of Biosciences, University of Milan"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1162825"],"scientific_name":["Homo sapiens"],"long_description":["We genereted via genome editing 293T cell lines with the heterozygous and homozygous nucleotide substitution c.1424A>G in the PNPT1 gene (namely EK81 and EK81.8, respectively), causing the amino acidic variation p.E475G, and studied their transcriptomes before and after 6 hours of treatment with 1 µM staurosporine to induce apoptosis Overall design: Comparative RNA expression analysis of RNA-seq data for 293T cells and its derivatives EK81 and EK81.8"],"repository":["ENA"],"description_synonyms":["old-35, HEK293T, Human Embryonic Kidney 293T, DFNB70, Materials, Transcriptome, Genetic, 293-T, 1200003F12Rik, 293tsA1609neo, Transcriptome Profile, Profile, COXPD13, Expression Profiles, Gene Expression Profile, Gene, HEK 293 T, PNPase, OLD35, INSDC_feature:gene, Profiles, Cistrons, 293 T, Signatures, 293T, Mutations, Pnptl1, Hek 293T, whole transcriptome, Old35, Gene Expression, HEK-293T, Material, Expression Signature, Gene Expression Profiles, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Transcriptomes, Genetic Materials, Cistron, PNPASE, Gene Expression Signature, Signature, Expression Profile, Genetic Material, HEK-293-T, RCB2202"],"name_synonyms":["old-35, HEK293T, Human Embryonic Kidney 293T, DFNB70, Materials, Transcriptome, Genetic, 293-T, 1200003F12Rik, 293tsA1609neo, Transcriptome Profile, Profile, COXPD13, Expression Profiles, Gene Expression Profile, Gene, HEK 293 T, PNPase, OLD35, INSDC_feature:gene, Profiles, Cistrons, 293 T, Signatures, 293T, Mutations, Pnptl1, Hek 293T, whole transcriptome, Old35, Gene Expression, HEK-293T, Material, Expression Signature, Gene Expression Profiles, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Transcriptomes, Genetic Materials, Cistron, PNPASE, Gene Expression Signature, Signature, Expression Profile, Genetic Material, HEK-293-T, RCB2202"],"additional_accession":[]},"is_claimable":false,"name":"Effect of p.E475G mutation in the PNPT1 gene on 293T global transcriptome","description":"Effect of p.E475G mutation in the PNPT1 gene on 293T global transcriptome","dates":{"last_updated":"2025-09-24","first_public":"2024-10-09"},"accession":"PRJNA1162825","cross_references":{"GEO":["GSE277568"],"taxon":["9606"]}}