{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["NYU Langone Health"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1162859"],"scientific_name":["Homo sapiens"],"long_description":["Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperreactive platelet phenotype, which is thought to contribute to the high incidence of thrombosis in COVID-19 patients. Mutations of SARS-CoV-2 resulted in several virus variants with differences in transmissibility, infectivity and mortality. This study was designed to investigate how SARS-CoV-2 variants of concern, delta and omicron, affect the transcriptome and function of megakaryocytes (MKs) relative to the ancestral WA1 strain. Overall design: Human CD34+-derived megakaryocytes from 4 unvaccinated COVID-19 donors were infected with WA1, Delta or Omicron SARS-CoV-2 variants or vehicle control for 24 hours."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and Transcriptome","description":"Effects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and Transcriptome","dates":{"last_updated":"2025-09-24","first_public":"2025-09-08"},"accession":"PRJNA1162859","cross_references":{"GEO":["GSE277576"],"taxon":["9606"]}}