ENAGenomicsNYU Langone Healthhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1162859Homo sapiensSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperreactive platelet phenotype, which is thought to contribute to the high incidence of thrombosis in COVID-19 patients. Mutations of SARS-CoV-2 resulted in several virus variants with differences in transmissibility, infectivity and mortality. This study was designed to investigate how SARS-CoV-2 variants of concern, delta and omicron, affect the transcriptome and function of megakaryocytes (MKs) relative to the ancestral WA1 strain. Overall design: Human CD34+-derived megakaryocytes from 4 unvaccinated COVID-19 donors were infected with WA1, Delta or Omicron SARS-CoV-2 variants or vehicle control for 24 hours.ENAfalseEffects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and TranscriptomeEffects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and Transcriptome2025-09-242025-09-08PRJNA1162859GSE2775769606