{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Lakhani Lab, UQ Centre for Clinical Research, The University of Queensland"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1168525"],"scientific_name":["Homo sapiens"],"long_description":["Metaplastic breast cancer (MpBC) is a rare and aggressive form of breast cancer. Characteristically heterogeneous, MpBC are defined by the presence of various morphological elements, typically biphasic, with epithelial (e.g. non-special type (NST), squamous) and mesenchymal (e.g. spindle, chondroid, osteoid) components. The established clonality of the different components, favours an evolution model encompassing either a multipotent progenitor, or a linear metaplastic conversion. Our study defines the micro-methylome and a spatial transcriptomic profile in MpBC, and identifies potential drivers associated with tumor heterogeneity that supports the conversion model of metaplasia and warrants further functional analysis. Overall design: This submission includes only methylation arrays. Illumina Human Methylation EPIC BeadChip used for FFPE-origin DNA."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Methylation and Spatial Transcriptomic Profiling of Metaplastic Breast Cancer identifies putative master regulators of intratumoral heterogeneity","description":"Integrated Methylation and Spatial Transcriptomic Profiling of Metaplastic Breast Cancer identifies putative master regulators of intratumoral heterogeneity","dates":{"last_updated":"2025-09-24","first_public":"2025-08-14"},"accession":"PRJNA1168525","cross_references":{"GEO":["GSE278722"],"taxon":["9606"]}}