{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/072/SRR31555972/SRR31555972.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/076/SRR31555976/SRR31555976.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/075/SRR31555975/SRR31555975.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/071/SRR31555971/SRR31555971.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/073/SRR31555973/SRR31555973.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/068/SRR31555968/SRR31555968.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/069/SRR31555969/SRR31555969.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/070/SRR31555970/SRR31555970.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/074/SRR31555974/SRR31555974.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR315/067/SRR31555967/SRR31555967.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["City of hope"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1192315"],"scientific_name":["Mus"],"tag":["xref:PubMed:39856052"],"long_description":["NKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. Here, we show that NKp46 is indispensable for expressing IL-2 receptor-α (IL-2Rα) by non-NK liver-resident type-1 innate lymphoid cells (ILC1s). Deletion of NKp46 reduces IL-2Rα on ILC1s by downregulating NF-κB signaling, thus impairing ILC1 proliferation and cytotoxicity in vitro and in vivo. Likewise, the binding of anti-NKp46 antibody to NKp46 triggers the activation of NF-κB, the expression of IL-2Rα, interferon- γ (IFN-γ), tumor necrosis factor (TNF), proliferation, and cytotoxicity. Functionally, NKp46 expressed on mouse ILC1s interacts with tumor cells through cell–cell contact, increasing ILC1 production of IFN-γ and TNF, and enhancing cytotoxicity. In a mouse model of acute myeloid leukemia (AML), deletion of NKp46 impairs the ability of ILC1s to control tumor growth and reduces survival. This can be reversed by injecting NKp46+ ILC1s into NKp46 knock-out mice. Human NKp46+ ILC1s exhibit stronger cytokine production and cytotoxicity than their NKp46 counterparts, suggesting that NKp46 plays a similar role in humans. These findings identify an NKp46–NF-κB–IL-2Rα axis and suggest that activating NKp46 with an anti-NKp46 antibody, may provide a potential strategy for anti-tumor innate immunity. Overall design: Comparison of the differences between Ncr1⁺/⁺ ILC1s and Ncr1gfp/gfp ILC1s"],"repository":["ENA"],"description_synonyms":["Myelogenous Leukemias, Myelocytic, leukemia, Myelogenous, MGC130048, Multiplication, Acute Myeloblastic, acute myeloblastic leukemia, M1, M2, Cellular Proliferation, SGCG_HUMAN, acute myelogenous leukemia, Activity, 35 kDa dystrophin-associated glycoprotein, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, acute myeloblastic leukaemia, acute myelogenous leukaemia, SG-gamma, Myelocytic Leukemia, A4, function, TYPE, Cell, Cell Growth in Number, Leukemias, Acute Myeloid, SGCG, LGMD2C, Acute Myelocytic Leukemias, AML, DAGA4, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, Nonlymphoblastic, acute non lymphoblastic leukaemia, Acute Myeloid Leukemias, Myeloid Leukemias, 35DAG, Cell Number Growth, Acute Myelocytic, Acute Nonlymphoblastic, Cellular, sarcoglycan, acute myeloid, Number Growth, MAM, gamma-SG, Acute Nonlymphocytic, SCG3, Myeloblastic Leukemia, Acute Myelogenous Leukemia, acute, gamma sarcoglycan, Acute myelogenous leukemia, Growth, Leukemia, DMDA1, Myeloblastic, Acute Myelogenous, Acute Myeloblastic Leukemia, susceptibility to, Myeloblastic Leukemias, General activity., Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, gamma (35kDa dystrophin-associated glycoprotein), Nonlymphocytic, Acute Myeloid Leukemia without Maturation, Acute Myeloid Leukemia with Maturation, cell proliferation, DMDA, Acute, Acute Nonlymphoblastic Leukemia, Acute Nonlymphocytic Leukemia, Acute Nonlymphoblastic Leukemias, 35kD dystrophin-associated glycoprotein, Proliferation, Acute Myeloblastic Leukemias, SCARMD2, Cell Multiplication, Myeloid Leukemia, Acute Myelogenous Leukemias, Myelocytic Leukemias, Cell Number, gamma-sarcoglycan, ANLL, Nonlymphoblastic Leukemias, AML - acute Myeloid Leukemia, acute myelogenous"],"name_synonyms":["Myelogenous Leukemias, Myelocytic, leukemia, Myelogenous, MGC130048, Multiplication, Acute Myeloblastic, acute myeloblastic leukemia, M1, M2, Cellular Proliferation, SGCG_HUMAN, acute myelogenous leukemia, Activity, 35 kDa dystrophin-associated glycoprotein, Nonlymphocytic Leukemia, acute non lymphoblastic leukemia, Myeloid, acute myeloblastic leukaemia, acute myelogenous leukaemia, SG-gamma, Myelocytic Leukemia, A4, function, TYPE, Cell, Cell Growth in Number, Leukemias, Acute Myeloid, SGCG, LGMD2C, Acute Myelocytic Leukemias, AML, DAGA4, Acute Myelocytic Leukemia, Nonlymphoblastic Leukemia, Nonlymphocytic Leukemias, Nonlymphoblastic, acute non lymphoblastic leukaemia, Acute Myeloid Leukemias, Myeloid Leukemias, 35DAG, Cell Number Growth, Acute Myelocytic, Acute Nonlymphoblastic, Cellular, sarcoglycan, acute myeloid, Number Growth, MAM, gamma-SG, Acute Nonlymphocytic, SCG3, Myeloblastic Leukemia, Acute Myelogenous Leukemia, acute, gamma sarcoglycan, Acute myelogenous leukemia, Growth, Leukemia, DMDA1, Myeloblastic, Acute Myelogenous, Acute Myeloblastic Leukemia, susceptibility to, Myeloblastic Leukemias, General activity., Acute Myeloid Leukemia, acute myeloid leukemia, acute myeloid leukaemia, Myelogenous Leukemia, Acute Nonlymphocytic Leukemias, gamma (35kDa dystrophin-associated glycoprotein), Nonlymphocytic, Acute Myeloid Leukemia without Maturation, Acute Myeloid Leukemia with Maturation, cell proliferation, DMDA, Acute, Acute Nonlymphoblastic Leukemia, Acute Nonlymphocytic Leukemia, Acute Nonlymphoblastic Leukemias, 35kD dystrophin-associated glycoprotein, Proliferation, Acute Myeloblastic Leukemias, SCARMD2, Cell Multiplication, Myeloid Leukemia, Acute Myelogenous Leukemias, Myelocytic Leukemias, Cell Number, gamma-sarcoglycan, ANLL, Nonlymphoblastic Leukemias, AML - acute Myeloid Leukemia, acute myelogenous"],"additional_accession":[]},"is_claimable":false,"name":"NKp46 regulates type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity","description":"NKp46 regulates type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity","dates":{"last_updated":"2025-02-23","first_public":"2024-12-06"},"accession":"PRJNA1192315","cross_references":{"GEO":["GSE283199"],"taxon":["10088"],"PubMed":["39856052"]}}