{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["New Projects Development Division, Toray Industries,Inc."],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1210576"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:26718911"],"long_description":["Radiation-resistant of acute myeloid leukemia cell present challenges to treatment, and the acquisition of resistance to ionizing radiation (IR) is a matter of clinical concern. However, little information is available on the behavior of radio-resistant leukemia in terms of gene expression profiles and intercellular communication. In this study, mRNA microarray was used to analyze the intracellular genetic network in the established radio-resistant HL60 (Res-HL60) cell line. Significant changes in the expression of 7,309 known mRNAs were observed in Res-HL60 relative to control. In addition, 7 mRNAs were determined as targets because significant changes in the expression were observed using Ingenuity analysis software, confirming the quantitative RT-PCR. However, extracellular vesicles from Res-HL60 cells did not include these target mRNAs. These results suggest that radio-resistant leukemia model is regulated by the expression and suppression of specific mRNAs, and these molecules are not transferred between cells by extracellular vesicles. Overall design: Human acute myeloid leukemia cell line HL60 was prepared after frequent irradiation (4Gy X-irradiation ×4 fractions per 4 weeks) with confirmed radiation-resistance characteristics. The extracted total RNA in wild type cell and radiation-resistant cell were performed messenger RNA (mRNA) microarray and calculate the expression of mRNAs."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Genetic network profiles associated with established resistance to ionizing radiation in leukemia cell line HL60","description":"Genetic network profiles associated with established resistance to ionizing radiation in leukemia cell line HL60","dates":{"last_updated":"2025-09-24","first_public":"2025-01-30"},"accession":"PRJNA1210576","cross_references":{"GEO":["GSE286939"],"taxon":["9606"],"PubMed":["26718911"]}}