ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/058/SRR33239858/SRR33239858_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/048/SRR33239848/SRR33239848_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/052/SRR33239852/SRR33239852_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/060/SRR33239860/SRR33239860_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/048/SRR33239848/SRR33239848_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/046/SRR33239846/SRR33239846_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/059/SRR33239859/SRR33239859_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/060/SRR33239860/SRR33239860_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/061/SRR33239861/SRR33239861_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/051/SRR33239851/SRR33239851_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/051/SRR33239851/SRR33239851_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/049/SRR33239849/SRR33239849_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/061/SRR33239861/SRR33239861_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/049/SRR33239849/SRR33239849_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/046/SRR33239846/SRR33239846_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/059/SRR33239859/SRR33239859_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/058/SRR33239858/SRR33239858_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/052/SRR33239852/SRR33239852_1.fastq.gzftp://primaryOK200GenomicsStanfordhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1253759Mus musculusThe transcription factor TCF-1 is downregulated during effector differentiation of CD8+ T cells. However, how its downregulation impacts epigenetic regulation of different effector- and memory-biased populations remains unclear. Here, we generate mice in which TCF-1 fails to become downregulated in differentiated effector cells and probe the epigenetic impact of TCF-1 retention on gene accessibiltiy patterns and moif enrichment patterns in CD8+ T cells on 8 dpi with LCMV-13 using scATAC-seq. Overall design: CD8+ T cells specific to the LCMV-gp3 antigen were sorted from the spleens of two WT control and two Tcf7+22kb mice on 8 dpi with LCMV-Armstrong. Samples were subjected to scATAC-sequencing.ENAfalseEffects of TCF-1 de-repression on heterogeneity of chromatin states in memory and effector cells following acute infecton [scATAC-seq]Effects of TCF-1 de-repression on heterogeneity of chromatin states in memory and effector cells following acute infecton [scATAC-seq]2025-09-242025-06-01PRJNA1253759GSE29524710090