ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/055/SRR33253755/SRR33253755_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/059/SRR33253759/SRR33253759_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/057/SRR33253757/SRR33253757_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/060/SRR33253760/SRR33253760_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/056/SRR33253756/SRR33253756_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/065/SRR33253765/SRR33253765_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/060/SRR33253760/SRR33253760_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/054/SRR33253754/SRR33253754_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/061/SRR33253761/SRR33253761_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/058/SRR33253758/SRR33253758_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/055/SRR33253755/SRR33253755_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/066/SRR33253766/SRR33253766_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/064/SRR33253764/SRR33253764_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/063/SRR33253763/SRR33253763_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/057/SRR33253757/SRR33253757_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/061/SRR33253761/SRR33253761_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/065/SRR33253765/SRR33253765_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/063/SRR33253763/SRR33253763_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/062/SRR33253762/SRR33253762_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/059/SRR33253759/SRR33253759_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/058/SRR33253758/SRR33253758_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/062/SRR33253762/SRR33253762_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/064/SRR33253764/SRR33253764_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/066/SRR33253766/SRR33253766_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/056/SRR33253756/SRR33253756_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR332/054/SRR33253754/SRR33253754_2.fastq.gzprimaryOK200GenomicsUniversity Medical Center Mainzhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1254225Mus musculusHere, we set out to study the impact of gut commensals and TLR2 signaling on the vascular inflammatory phenotype of acute mesenteric I/R injured venules. Taking advantage of gnotobiotic experimentation and an endothelial-specific Tlr2-deficient mouse model, we dissect whether I/R-induced NETosis is also supported by endothelial TLR2 activation. To resolve the engagement of microbiota-induced TLR2 signaling on neutrophil function, based on agonist-treatment, we pinpoint the role of TLR2/1 vs TLR2/6 signaling in ex vivo NETosis induction. Overall design: RNA-seq profiling transcriptome of liver endothelial cells of conventionally raised (CONV-R) and germ-free (GF) mice.ENAfalseThe gut microbiota regulates the vascular inflammatory phenotype in mesenteric ischemia-reperfusion injury via endothelial Toll-like receptor-2 signalingThe gut microbiota regulates the vascular inflammatory phenotype in mesenteric ischemia-reperfusion injury via endothelial Toll-like receptor-2 signaling2025-09-242025-04-25PRJNA1254225GSE29533810090