{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Mayo Clinic"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1268607"],"scientific_name":["Homo sapiens"],"long_description":["Frontotemporal lobar degeneration (FTLD) is one of the leading causes of dementia in individuals younger than 65 years, with the aggregation of TDP-43 as one of the most common forms of FTLD. FTLD-TDP is clinically, genetically and pathologically heterogeneous, with GRN and C9orf72 as the most common genetic forms (although more than 50% of the cases are genetically unexplained), and A, B and C as the most common pathological subtypes. To investigate the molecular differences between the different forms of FTLD-TDP, we performed bulk RNA sequencing (RNAseq) and reduced representation bisulfite sequencing (RRBS) from different brain regions of FTLD-TDP patients and controls. The RNAseq dataset includes samples from the frontal cortex of 149 individuals, comprising 127 FTLD-TDP cases... (for more see dbGaP study page.)"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"RNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls","description":"RNA transcriptomic and DNA methylation landscape in FTLD-TDP and controls","dates":{"last_updated":"2025-09-24","first_public":"2025-06-29"},"accession":"PRJNA1268607","cross_references":{"taxon":["9606"]}}