{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Institute of Biochemistry, Charité Universitaetsmedizin Berlin"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA128061"],"scientific_name":["Homo sapiens"],"long_description":["Coordinated regulation of the ubiquitin-proteasome system is crucial for the cell to adjust its protein degradation capacity to changing proteolytic requirements. The transcription factor TCF11 has been identified as a regulator for 26S-proteasome formation in human cells to compensate for reduced proteolytic activity. To expand the current knowledge of other UPS-related TCF11 target genes in response to epoxomicin, we performed microarray analyses of cells exposed to epoxomicin and with or without depletion of TCF11. Keywords: siRNA depletion Overall design: Human Ea.hy926 cells were harvested 24 hours following treatment with 10nM epoxomicin or DMSO as a solvent control and with transfection of control siRNA or TCF11-specific siRNA for RNA extraction and hybridization on Affymetrix microarrays."],"tag":["xref:PubMed:20932482"],"repository":["ENA"],"description_synonyms":["N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-L-threoninamide, human being, Man (Taxonomy), NRF1, Modern, TCF-11, number, Lcrf1, AW212678, human, Cell, NICR2148, presence., Human, L-threoninamide, count in organism, AA408798, TCF11, Homo sapiens, EA.hy926, EA.hy926 cell, Modern Man, EA.hy926 细胞, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-, Man, LCR-F1"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Expression data from human Ea.hy926 cells in response to epoxomicin and in dependency of TCF11 presence","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA128061","cross_references":{"GEO":["GSE22853"],"taxon":["9606"],"PubMed":["20932482"]}}