ENAGenomicsInstitute of Biochemistry, Charité Universitaetsmedizin Berlinhttps://www.ebi.ac.uk/ena/browser/view/PRJNA128061Homo sapiensCoordinated regulation of the ubiquitin-proteasome system is crucial for the cell to adjust its protein degradation capacity to changing proteolytic requirements. The transcription factor TCF11 has been identified as a regulator for 26S-proteasome formation in human cells to compensate for reduced proteolytic activity. To expand the current knowledge of other UPS-related TCF11 target genes in response to epoxomicin, we performed microarray analyses of cells exposed to epoxomicin and with or without depletion of TCF11. Keywords: siRNA depletion Overall design: Human Ea.hy926 cells were harvested 24 hours following treatment with 10nM epoxomicin or DMSO as a solvent control and with transfection of control siRNA or TCF11-specific siRNA for RNA extraction and hybridization on Affymetrix microarrays.xref:PubMed:20932482ENAN-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-L-threoninamide, human being, Man (Taxonomy), NRF1, Modern, TCF-11, number, Lcrf1, AW212678, human, Cell, NICR2148, presence., Human, L-threoninamide, count in organism, AA408798, TCF11, Homo sapiens, EA.hy926, EA.hy926 cell, Modern Man, EA.hy926 细胞, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-, Man, LCR-F1Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern ManfalseHomo sapiensExpression data from human Ea.hy926 cells in response to epoxomicin and in dependency of TCF11 presence2025-09-242014-02-11PRJNA128061GSE22853960620932482