{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Jiangsu Cancer Hospital"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1283220"],"scientific_name":["Homo sapiens"],"long_description":["The limited response rate to immune checkpoint inhibitors (ICIs) remains a significant challenge in the treatment of lung adenocarcinoma (LUAD). In our study, we identified a lactate-based chemical barrier surrounding FAP+ cancer-associated fibroblasts (CAFs) within the LUAD microenvironment (TME), which may hinder the infiltration and function of CD8+ T cells. Further investigation revealed that FAP+ CAFs specifically overexpress LINC01711. Hence, we performed RNA-seq in FAP+ CAFs, FAP- CAFs and FAP+ CAFs-siLINC01711, FAP+ CAFs-siNC cells. Overall design: Hence, we performed RNA-seq in FAP+ CAFs vs. FAP- CAFs and FAP+ CAFs-siLINC01711 vs. FAP+ CAFs-siNC cells."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Targeting LINC01711 in FAP+ cancer-associated fibroblasts in lung adenocarcinoma","description":"Targeting LINC01711 in FAP+ cancer-associated fibroblasts in lung adenocarcinoma","dates":{"last_updated":"2025-09-24","first_public":"2025-07-04"},"accession":"PRJNA1283220","cross_references":{"GEO":["GSE301076"],"taxon":["9606"]}}