ENAGenomicsMax Delbrueck Center Berlinhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1285140The goal of the study is to establish Prime Editing (PE) in differentiated, non-dividing human cardiomyocytes to precisely repair patient-derived DCM mutations to wildtype. We focus on three pathogenic DCM-causing mutations within the human LMNA and RBM20 genes. Our results support further pre-clinical development of PE-based therapies, particularly for RBM20-P633L-associated DCMENAfalsePrime Editing Corrects RBM20-Mediated Dilated Cardiomyopathy in Human Cardiomyocytes2025-07-042025-07-04PRJNA1285140