{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["East China Normal University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1287740"],"scientific_name":["Mus musculus"],"long_description":["This study investigates the impact of Prdm12 knockout on chromatin accessibility in CD8+ T cells. CD8+ T cells were isolated from spleens of OTI:Cas9 transgenic mice (C57BL/6 background) using magnetic bead-based negative selection. Isolated cells were subjected to CRISPR-Cas9 mediated gene editing targeting Prdm12 (Prdm12-KO group) or a non-targeting control guide RNA (Control group) via ribonucleoprotein (RNP) complex electroporation. ATAC-seq was performed to compare genome-wide chromatin accessibility between edited (treatment) and non-edited (control) cells, aiming to identify regulatory regions associated with Prdm12 function. Overall design: Comparative analysis of chromatin accessibility in CD8+ T cells with and without Prdm12 knockout.Two experimental groups were established:Treatment group: CD8+ T cells edited with Prdm12-targeting RNP Control group: Non-edited CD8+ T cells.Chromatin accessibility was profiled using ATAC-seq for both groups. The experiment aims to identify differentially accessible regulatory regions influenced by Prdm12 deletion."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide chromatin accessibility profiling of Prdm12-edited CD8+ T cells by ATAC-seq","description":"Genome-wide chromatin accessibility profiling of Prdm12-edited CD8+ T cells by ATAC-seq","dates":{"last_updated":"2025-09-24","first_public":"2025-09-08"},"accession":"PRJNA1287740","cross_references":{"GEO":["GSE301907"],"taxon":["10090"]}}