{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["University of Leicester"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1292377"],"scientific_name":["Homo sapiens"],"long_description":["Peroxiredoxin 3 (PRX3), a mitochondrial matrix antioxidant enzyme, regulates reactive oxygen species (ROS) homeostasis and promotes tumor cell survival. Our functional screening experiments have proved that PRX3 inhibitor, thiostrepton (TS), plays a tumor suppressive role in vitro and in vivo. Hence, we design the patent derived explants experiement to explore the transcriptional exchange under TS treatment. All samples were derived from human mesothelioma tumour tissue, collected during extended pleurectomy/decortication (EPD) surgery as part of the MEDUSA cohort. Tumour tissue was snap-frozen immediately after surgical resection (FF1). UC1 samples were cultured for 24 hours in standard tissue culture media, and TS samples were cultured for 24 hours in media containing TS inhibitor."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Patient derived explants for PRDX3 inhibitor study","dates":{"last_updated":"2025-07-18","first_public":"2025-07-18"},"accession":"PRJNA1292377","cross_references":{"taxon":["9606"]}}