{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["College of Pharmacy, Ewha Womans Univ."],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA130169"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:21738571"],"long_description":["Heat shock response (HSR) is a cellular defense mechanism against various stresses. Both heat shock and proteasome inhibitor MG132 cause the induction of heat shock proteins, a distinct feature of HSR. To better understand the molecular basis of HSR, we subjected the mouse fibrosarcoma cell line, RIF-1, and its thermotolerant variant, TR-RIF-1 cells, to heat shock and MG132. We compared mRNA expressions using microarray analysis during recovery after heat shock and MG132 treatment. This study led us to group the 3,245 up-regulated genes by heat shock and MG132 into three families: genes regulated 1) by both heat shock and MG132 (e.g. chaperones) 2) by heat shock (e.g. DNA-binding proteins including histones) and 3) by MG132 (e.g. innate immunity and defense-related molecules). Overall design: RIF-1 and TR cells were heat shock treated or MG132 treated and harvested after various times of recovery. mRNA expressions were compared to untreated samples. Biological replication was done."],"repository":["ENA"],"description_synonyms":["Shock, Temperature, reactivity, Mus musculus, Proteasome Inhibitor, Laboratory, Circulatory, Swiss, mice, Mus domesticus, Proteasome Endopeptidase Complex Inhibitors, mouse, Swiss Mouse, House Mice, Swiss Mice, Circulatory Failure, fibrosarcoma of soft tissue, Fibrosarcomas, House Mouse, Failure, fibrosarcoma, Proteasome, domesticus, Laboratory Mice, Hypovolemic Shock, Circulatory Collapse, Collapse, Fibrocytic tumor, Hypovolemic, Temperatures, House, Mus, Hot, responsivity, Mus musculus domesticus, Heat, Hot Temperatures, Inhibitors, Cell., Mouse, response, house mouse, fibrous tissue neoplasm, Inhibitor, Mice, Laboratory Mouse"],"name_synonyms":["Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscaris"],"additional_accession":[]},"is_claimable":false,"name":"Mus musculus","description":"Systemic Comparison of Heat Shock Response Induced by Heat Shock and a Proteasome Inhibitor in Mouse Fibrosarcoma Cells and Their Thermotolerant Counterparts","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA130169","cross_references":{"GEO":["GSE24197"],"taxon":["10090"],"PubMed":["21738571"]}}