ENAGenomicsRWTH Aachen University Hospitalhttps://www.ebi.ac.uk/ena/browser/view/PRJNA1303991IgA is the most abundantly produced antibody isotype and mediates protection and homeostatic regulation at mucosal surfaces. Steady state IgA production is supported by multiple pathways, including chronic germinal centers in gut inductive lymphoid tissues, but we lack a detailed understanding of how IgA responses are integrated across inductive and effector sites, and in time. Here, we dissect homeostatic IgA responses from the perspective of clonal repertoires in inductive compartments and the gut lamina propria as main effector compartment. We show that unique clonal patterns dominate across gut inductive sites and that plasma cell clones in gut lamina propria entail progressive stages of differentiation. We demonstrate that ongoing diversification of recurrent clones continuously seeds the gut plasma cell population. These observations suggest that clonal rather than cellular longevity shapes IgA responses and that dynamic modulation of recurrent clones may balance stability and flexibility of the gut PC repertoire.ENAfalseClonal persistence dominates homeostatic intestinal IgA responses2025-08-142025-08-14PRJNA1303991