{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Peking University - Third School of Clinical Medicine: Peking University Third Hospital"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA1313185"],"long_description":["we generated a FHOD3 knockout (FHOD3-/-) human embryonic stem cell (hESC) cell line (H9) by CRISPR/Cas9 system and differentiate it into cardiomyocytes to elucidate the mechanism of cardiomyopathy and HF caused by FHOD3 deficiency. Our study found that FHOD3-deficient hPSC-CMs presented sarcomere disorganization and degradation. In addtion, impaired calcium homeostasis aggravated the pathogenesis of myocardial dysfunction and HF."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"","description":"fhod3 deficiency leads to cardiomyopathy in hESC-CMs","dates":{"last_updated":"2025-09-08","first_public":"2025-09-08"},"accession":"PRJNA1313185","cross_references":{}}