{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"center_name":["University of Michigan"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA136955"],"scientific_name":["Homo sapiens"],"long_description":["Systemic lupus erythematosus (SLE) is characterized by increased vascular risk due to premature atherosclerosis independent of traditional risk factors. We previously proposed that interferon-α plays a crucial role in premature vascular damage in SLE. IFN-α alters the balance between endothelial cell apoptosis and vascular repair mediated by endothelial progenitor cells (EPCs) and myeloid circulating angiogenic cells (CACs). Here we demonstrate that IFN-α promotes an antiangiogenic signature in SLE and control EPCs/CACs, characterized by transcriptional repression of IL-1α and β, IL-1 receptor 1 and vascular endothelial growth factor A (VEGF-A) and upregulation of IL-1 receptor antagonist (IL-1RN) and the decoy receptor IL1-R2. IL-1β promotes significant improvement in the functional capacity of lupus EPCs/CACs, therefore abrogating the deleterious effects of IFN-α. We used microarrays to analyze the effect of IFNα on peripheral blood EPCs/CACs and on bone marrow EPCs exposed to proangiogenic stimulation. Overall design: Human lupus EPCs and CACs from PBMCs were isolated and cultured under proangiogenic stimulation after IFNa incubation or not, RNA was extracted and processed for hybridization on Affymetrix microarrays."],"tag":["xref:PubMed:20805419","xref:PubMed:22058412"],"repository":["ENA"],"description_synonyms":["data, Disease, lupus erythematosus, human being, Libman Sacks Disease, Man (Taxonomy), Systemic, lupus, SLE, Lupus Erythematosus Disseminatus, Modern, susceptibility to, ER-PM contact site, Lupus Erythematosus, endoplasmic reticulum-plasma membrane contact junction., man, human, Human, LIBMAN SACKS DIS, Homo sapiens, Libman-Sacks Disease, ER-plasma membrane contact site, Modern Man, excess LMW-DNA, Libman-Sacks, lupus nephritis, Man, EPCS, excess lymphocyte low molecular weight DNA"],"name_synonyms":["Human, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Man"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Expression data from human lupus EPCs/CACs","dates":{"last_updated":"2025-09-24","first_public":"2014-02-11"},"accession":"PRJNA136955","cross_references":{"GEO":["GSE26950"],"taxon":["9606"],"PubMed":["20805419","22058412"]}}