ENAGenomicsUniversity of Michiganhttps://www.ebi.ac.uk/ena/browser/view/PRJNA137639Mus musculusxref:PubMed:21411733Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune complex deposition. Our findings suggest that mononuclear phagocytes with an aberrant activation profile contribute to tissue damage in lupus nephritis by mediating both local inflammation and excessive tissue remodeling. We used microarrays to analyze the gene expression of renal isolated macrophages at early stage of lupus (young) during lupus nephritis (sick) and after induction of remission (Rem) Overall design: NZB/W F4/80hi mouse cells were isolated using flow cytometry RNA from cells (young, sick and after complete remission) was extracted and processed for hybridization on Affymetrix microarrays.ENAMus musculus, Disease, lupus erythematosus, Libman Sacks Disease, Systemic, Monocyte Derived Macrophages, Laboratory, Macrophages, Swiss, lupus, SLE, mice, Lupus Erythematosus Disseminatus, susceptibility to, Mus domesticus, mouse, Swiss Mouse, Bone Marrow Derived Macrophages, House Mice, Swiss Mice, Bone Marrow-Derived Macrophage, Monocyte Derived, Lupus Erythematosus, House Mouse, domesticus, Laboratory Mice, Bone Marrow-Derived, Kidneys, Monocyte-Derived, LIBMAN SACKS DIS, House, Mus, Libman-Sacks Disease, excess LMW-DNA, disease remission., Bone Marrow-Derived Macrophages, Monocyte-Derived Macrophage, Mus musculus domesticus, Mouse, Libman-Sacks, house mouse, lupus nephritis, Mice, Laboratory Mouse, Monocyte-Derived Macrophages, Macrophage, excess lymphocyte low molecular weight DNAMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusExpression data from macrophages isolated from lupus NZB/W mouse kidneys prenephritic, nephritic or after complete remission.2025-09-242014-02-11PRJNA137639GSE270451009021411733