{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR285/SRR285020/SRR285020_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR285/SRR285020/SRR285020_1.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Epigenetics, Diabetes, Blizard Institute"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA140771"],"scientific_name":["Apis mellifera"],"long_description":["Here, we demonstrate that Nematostella vectensis, Ciona intestinalis, Apis mellifera, and B. mori, show two distinct populations of genes differentiated by gene-body CpG density. Genome-scale DNA methylation profiles for A. mellifera spermatozoa reveal CpG-poor genes are methylated in the germ line, as predicted by the depletion of CpGs. We find an evolutionarily conserved distinction between CpG-poor and -rich genes: the former are associated with basic biological processes, the latter with more specialized functions. This distinction is strikingly similar to that recently observed between euchromatin-associated genes in Drosophila that contain intragenic histone 3 lysine 36 trimethylation (H3K36me3) and those that do not, even though Drosophila doesnât display CpG density bimodality or methylation. We confirm that a significant number of CpG-poor genes in N. vectensis, C. intestinalis, A. mellifera and B. mori are orthologs of H3K36me3- rich genes in Drosophila. We propose that over evolutionary time, gene-body H3K36me3 has influenced gene-body DNA methylation levels, and consequently the gene-body CpG density bimodality characteristic of invertebrates that harbor CpG methylation. Overall design: Examination of DNA methylation in Apis Mellifera sperm"],"tag":["xref:PubMed:21940836"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Apis mellifera","description":"Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates","dates":{"last_updated":"2025-09-24","first_public":"2013-05-31"},"accession":"PRJNA140771","cross_references":{"GEO":["GSE29982"],"taxon":["7460"],"PubMed":["21940836"]}}